PMID- 15251265
OWN - NLM
STAT- MEDLINE
DCOM- 20050126
LR  - 20191210
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 78
IP  - 3
DP  - 2004 Jul
TI  - Mnemonic effects of testosterone and its 5alpha-reduced metabolites in the 
      conditioned fear and inhibitory avoidance tasks.
PG  - 559-68
AB  - Experiments were conducted to examine whether performance in 
      hippocampally-mediated learning tasks is influenced by testosterone (T) and/or 
      its 5alpha-reduced metabolites, dihydrotestosterone (DHT) and 
      3alpha-androstanediol (3alpha-diol). Performance in the conditioned fear and 
      inhibitory avoidance tasks were examined in intact and gonadectomized (GDX), 
      androgen-replaced rats. In Experiment 1, the behavior of intact and GDX rats in 
      the conditioned fear paradigm were compared. GDX rats spent more time freezing, 
      an index of increased learning, in the context, hippocampally-mediated task, but 
      not in the cued, amygdala-mediated task. In Experiment 2, GDX rats were 
      administered T, DHT, 3alpha-diol, estrogen (E2), or vehicle 1 mg/kg sc after 
      training in the conditioned fear paradigm. T-, 3alpha-diol-, or E2-, compared 
      with vehicle-administered rats, spent significantly more time freezing in the 
      contextual, but not the cued, condition. In Experiment 3, intact compared with 
      GDX rats had significantly longer crossover latencies, indicating better 
      performance, in the inhibitory avoidance task. In Experiment 4, T, DHT, 
      3alpha-diol, or vehicle 1 mg/kg sc was administered to GDX rats immediately 
      following training in the inhibitory avoidance task. Rats administered T, DHT, or 
      3alpha-diol had significantly longer crossover latencies compared with vehicle 
      controls. In Experiment 5, androgen levels in the hippocampus were elevated 1 h 
      following administration, when androgen exposure is essential for consolidation. 
      These data indicate that androgens effects to enhance learning may be mediated in 
      part by actions of 5alpha-reduced metabolites in the hippocampus.
FAU - Edinger, Kassandra L
AU  - Edinger KL
AD  - Department of Psychology, The University at Albany-SUNY, Social Science 220, 1400 
      Washington Avenue, Albany, NY 12222, USA.
FAU - Lee, Bomi
AU  - Lee B
FAU - Frye, Cheryl A
AU  - Frye CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 08J2K08A3Y (Dihydrotestosterone)
RN  - 25126-76-5 (Androstane-3,17-diol)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Androstane-3,17-diol/*pharmacology
MH  - Animals
MH  - Avoidance Learning/*drug effects
MH  - Conditioning, Psychological/*drug effects
MH  - Dihydrotestosterone/*pharmacology
MH  - Fear/*drug effects
MH  - Male
MH  - Memory/*drug effects
MH  - Rats
MH  - Rats, Long-Evans
MH  - Reaction Time/drug effects
MH  - Testosterone/*pharmacology
EDAT- 2004/07/15 05:00
MHDA- 2005/01/27 09:00
CRDT- 2004/07/15 05:00
PHST- 2004/02/20 00:00 [received]
PHST- 2004/03/31 00:00 [revised]
PHST- 2004/04/13 00:00 [accepted]
PHST- 2004/07/15 05:00 [pubmed]
PHST- 2005/01/27 09:00 [medline]
PHST- 2004/07/15 05:00 [entrez]
AID - S0091305704001522 [pii]
AID - 10.1016/j.pbb.2004.04.024 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2004 Jul;78(3):559-68. doi: 10.1016/j.pbb.2004.04.024.