PMID- 15254878
OWN - NLM
STAT- MEDLINE
DCOM- 20040831
LR  - 20220409
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 53
IP  - 7
DP  - 2004 Jul
TI  - Serum tumor necrosis factor-alpha levels and components of the metabolic syndrome 
      in obese adolescents.
PG  - 863-7
AB  - Tumor necrosis factor-alpha (TNF-alpha) seems to be increased in obese subjects, 
      suggesting its role as a proinflammatory cytokine to insulin resistance and 
      metabolic abnormalities in obesity. The aim of this study was to evaluate the 
      relationship between serum TNF-alpha, soluble TNF-alpha receptor 1 (sTNF-R1), 
      TNF-alpha receptor 2 (sTNF-R2), and metabolic syndrome (MS) components and 
      anthropometric indices in obese and non-obese adolescents. A cross-sectional 
      study was performed on obese and non-obese adolescents. We studied 71 adolescents 
      (age, 15 to 16 years old); 39 were obese (obese group; 14 males and 25 females) 
      and 32 were non-obese adolescents (non-obese lean group; 12 males and 20 
      females). The body mass index (BMI), waist circumference (WC), waist-to-hip ratio 
      (WHR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were 
      determined in each subject. The serum TNF-alpha, sTNF-R1, sTNF-R2, fasting plasma 
      glucose (FPG), and lipid profile were also measured. The mean serum TNF-alpha, 
      sTNF-R1, and sTNF-R2 were significantly higher in the obese than the non-obese 
      group (TNF-alpha, 18.15 v 5.88 pg/mL, P < .001; sTNF-R1, 2.01 v 1.40 ng/mL, P < 
      .001; sTNF-R2, 6.06 v 3.70 pg/mL, P < .001). The serum TNF-alpha concentrations 
      were positively correlated with the BMI (TNF-alpha, r = 0.346, P < .05; sTNF-R1, 
      r = 0.624, P < .001; sTNF-R2, r = 0.482, P < .001, respectively) and WC 
      (TNF-alpha, r = 0.525, P < .05; sTNF-R1, r = 0.700, P < .001; sTNF-R2, r = 0.669, 
      P < .001, respectively). The serum TNF-alpha was positively correlated with 
      triglyceride (TG) and DBP, and negatively with high-density 
      lipoprotein-cholesterol (HDLC). The sTNF-R1 and sTNF-R2 were correlated with TG 
      and DBP, and TG, respectively. Obese compared with non-obese adolescents 
      exhibited higher concentrations of TNF-alpha and its soluble receptors, and the 
      higher TNF-alpha concentrations were associated with several components of MS in 
      obese adolescents.
FAU - Moon, Yoo-Sun
AU  - Moon YS
AD  - Department of family Medicine, Hallym University College of Medicine, Chunchon, 
      Korea.
FAU - Kim, Do-Hoon
AU  - Kim DH
FAU - Song, Dong-Keun
AU  - Song DK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adolescent
MH  - Anthropometry
MH  - Blood Glucose/metabolism
MH  - Blood Pressure/physiology
MH  - Body Mass Index
MH  - Body Weight/physiology
MH  - Cholesterol/blood
MH  - Female
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - Metabolic Syndrome/*metabolism/physiopathology
MH  - Obesity/*metabolism
MH  - Receptors, Tumor Necrosis Factor/metabolism
MH  - Triglycerides/blood
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2004/07/16 05:00
MHDA- 2004/09/01 05:00
CRDT- 2004/07/16 05:00
PHST- 2004/07/16 05:00 [pubmed]
PHST- 2004/09/01 05:00 [medline]
PHST- 2004/07/16 05:00 [entrez]
AID - S0026049504001258 [pii]
AID - 10.1016/j.metabol.2004.02.007 [doi]
PST - ppublish
SO  - Metabolism. 2004 Jul;53(7):863-7. doi: 10.1016/j.metabol.2004.02.007.