PMID- 1525582
OWN - NLM
STAT- MEDLINE
DCOM- 19921016
LR  - 20141120
IS  - 1050-7256 (Print)
IS  - 1050-7256 (Linking)
VI  - 2
IP  - 2
DP  - 1992 Summer
TI  - Iodide induces transforming growth factor beta 1 (TGF-beta 1) mRNA in sheep 
      thyroid cells.
PG  - 141-5
AB  - We examined TGF-beta mRNA levels in primary sheep thyroid cell cultures to 
      determine whether the inhibitory effects of iodide on thyroid cells could be 
      explained by an induction of TGF-beta mRNA and if this induction was mediated by 
      iodine organification. Thyroid cells were incubated with TSH and five additives 
      (insulin, somatostatin, growth hormone, transferrin, and 
      glycyl-L-histidyl-L-lysin) for 2-3 weeks and then were exposed to sodium iodide 
      (NaI) or 1-methylimidazole-2-thiol (methimazole, MMI), or both for 72 h. Iodide 
      at 10(-6) M and 10(-4) M significantly increased the amount of TGF-beta mRNA as 
      determined by Northern blot analysis with a rat TGF-beta 1 cDNA probe. This 
      increase in TGF-beta 1 mRNA was abolished by the addition of methimazole, an 
      inhibitor of organification. These data indicate that the effects of iodide on 
      thyroid growth and function may be mediated by a process that involves 
      organification of iodide and increases in TGF-beta 1 mRNA levels.
FAU - Yuasa, R
AU  - Yuasa R
AD  - Department of Medicine, University of California, San Diego.
FAU - Eggo, M C
AU  - Eggo MC
FAU - Meinkoth, J
AU  - Meinkoth J
FAU - Dillmann, W H
AU  - Dillmann WH
FAU - Burrow, G N
AU  - Burrow GN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (RNA, Messenger)
RN  - 0 (Transforming Growth Factor beta)
RN  - 554Z48XN5E (Methimazole)
RN  - 9679TC07X4 (Iodine)
RN  - F5WR8N145C (Sodium Iodide)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Blotting, Northern
MH  - In Vitro Techniques
MH  - Iodine/*pharmacology
MH  - Methimazole/pharmacology
MH  - RNA, Messenger/*biosynthesis
MH  - Sheep
MH  - Sodium Iodide/pharmacology
MH  - Thyroid Gland/*drug effects/metabolism
MH  - Transforming Growth Factor beta/biosynthesis/*genetics
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1089/thy.1992.2.141 [doi]
PST - ppublish
SO  - Thyroid. 1992 Summer;2(2):141-5. doi: 10.1089/thy.1992.2.141.