PMID- 15256783
OWN - NLM
STAT- MEDLINE
DCOM- 20050125
LR  - 20190906
IS  - 0918-8959 (Print)
IS  - 0918-8959 (Linking)
VI  - 51
IP  - 3
DP  - 2004 Jun
TI  - Is thyroid follicular cancer in Japanese caused by a specific t(2; 3)(q13; p25) 
      translocation generating Pax8-PPAR gamma fusion mRNA?
PG  - 361-6
AB  - A recent western study reports that t(2; 3)(q13; p25) translocation resulting in 
      the expression of the Pax8-PPAR gamma fusion gene in patients with thyroid 
      follicular carcinoma (FTC) occurs with high incidence (63%). Furthermore, the 
      products of the fusion gene were shown to suppress the function of PPAR gamma in 
      a predominantly negative manner, conferring them with an oncogenic potential. We 
      examined the expression of this fusion gene in FTC in Japanese patients. From 
      1989 to 2000, six cases with FTC were surgically treated at our institute. In 
      these carcinoma samples, the expression of mRNAs for the Pax8-PPAR gamma fusion 
      product was analyzed by nested RT-PCR. Their expression was also studied in other 
      thyroid nodules (12 adenomatous goiters, 12 follicular adenomas, 12 papillary 
      carcinomas and 12 normal thyroid tissues) obtained at surgery during the same 
      period. Pax8-PPAR gamma fusion mRNA was not detected in any FTC samples nor in 
      the other samples. Furthermore, none of the 6 FTCs, one follicular adenoma or one 
      normal thyroid analyzed by fluorescence in situ hybridization (FISH) exhibited 
      Pax8-PPAR gamma gene fusion. These findings are in contrast to previous reports 
      and indicate that ethnic background may affect the translocation.
FAU - Hibi, Yatsuka
AU  - Hibi Y
AD  - Department of Endocrinology and Metabolism, Division of Molecular and Cellular 
      Adaptation, Institution of Environmental Medicine, Nagoya University, Chikusa-ku, 
      Nagoya 466-8601, Japan.
FAU - Nagaya, Takashi
AU  - Nagaya T
FAU - Kambe, Fukushi
AU  - Kambe F
FAU - Imai, Tsuneo
AU  - Imai T
FAU - Funahashi, Hiroomi
AU  - Funahashi H
FAU - Nakao, Akimasa
AU  - Nakao A
FAU - Seo, Hisao
AU  - Seo H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (PAX8 Transcription Factor)
RN  - 0 (PAX8 protein, human)
RN  - 0 (PPAR gamma)
RN  - 0 (Paired Box Transcription Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Adenocarcinoma, Follicular/*genetics
MH  - Alternative Splicing
MH  - Blotting, Northern
MH  - DNA-Binding Proteins/*genetics
MH  - Exons/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Japan
MH  - Nuclear Proteins/*genetics
MH  - Oncogene Proteins, Fusion/genetics
MH  - PAX8 Transcription Factor
MH  - PPAR gamma/*genetics
MH  - Paired Box Transcription Factors
MH  - RNA, Messenger/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Thyroid Neoplasms/*genetics
MH  - Trans-Activators/*genetics
MH  - *Translocation, Genetic
EDAT- 2004/07/17 05:00
MHDA- 2005/01/26 09:00
CRDT- 2004/07/17 05:00
PHST- 2004/07/17 05:00 [pubmed]
PHST- 2005/01/26 09:00 [medline]
PHST- 2004/07/17 05:00 [entrez]
AID - 10.1507/endocrj.51.361 [doi]
PST - ppublish
SO  - Endocr J. 2004 Jun;51(3):361-6. doi: 10.1507/endocrj.51.361.