PMID- 15256867
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1573-6814 (Electronic)
IS  - 1389-9333 (Linking)
VI  - 4
IP  - 1
DP  - 2003
TI  - Unrelated and related cord blood banking and hematopoietic graft engineering.
PG  - 29-35
AB  - The first successful transplantation of umbilical-cord blood (CB) was performed 
      in 1988 to treat a boy with Fanconi's anemia, using CB from his HLA full-matched 
      sister. A few years later, CB transplantation (CBT) was also performed in an 
      adult recipient, however major obstacles still prevent a wider application of CBT 
      in this age group. The principle limiting-factor is the low numbers of nucleated 
      (NC) and CD34+ cells available for transplantation compared to a typical bone 
      marrow (BM)/peripheral blood (PB) allograft, resulting in a lower engraftment 
      success as well as delayed hematopoietic recovery with its characteristic 
      complications, including infections and transplant related mortality (TRM). Other 
      problems include uncertainty regarding potency and efficacy of graft versus 
      leukemia (GvL)/tumor effects in this kind of transplant, considering the reduced 
      graft versus host disease (GvHD) manifestations and immunologic prematurity. 
      These subjects are reviewed with orientation to technical methods directed to 
      improve CB grafts and graft engineering.
FAU - Cohen, Yossi
AU  - Cohen Y
AD  - Department of Hematology.
FAU - Kreiser, Doron
AU  - Kreiser D
FAU - Mayorov, Margarita
AU  - Mayorov M
FAU - Nagler, Arnon
AU  - Nagler A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Cell Tissue Bank
JT  - Cell and tissue banking
JID - 100965121
EDAT- 2004/07/17 05:00
MHDA- 2004/07/17 05:00
CRDT- 2004/07/17 05:00
PHST- 2004/07/17 05:00 [pubmed]
PHST- 2004/07/17 05:00 [medline]
PHST- 2004/07/17 05:00 [entrez]
AID - 5142617 [pii]
AID - 10.1023/A:1026379514314 [doi]
PST - ppublish
SO  - Cell Tissue Bank. 2003;4(1):29-35. doi: 10.1023/A:1026379514314.