PMID- 15257044
OWN - NLM
STAT- MEDLINE
DCOM- 20040817
LR  - 20190713
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 78
IP  - 1
DP  - 2004 Jul 15
TI  - Assessment of optimal size and composition of the U.S. National Registry of 
      hematopoietic stem cell donors.
PG  - 89-95
AB  - BACKGROUND: The National Marrow Donor Program (NMDP) receives federal funding to 
      operate a registry of over 4 million volunteer donors for patients in need of a 
      hematopoietic stem cell transplant. Because minority patients are less likely to 
      find a suitably matched donor than whites, special efforts have been aimed toward 
      recruitment of minorities. Significant financial resources are required to 
      recruit and tissue type additional volunteer donors. METHODS: Population genetics 
      models have been constructed to project likelihoods of finding a human leukocyte 
      antigen (HLA)-matched donor for patients of various racial/ethnic groups. These 
      projections have been made under a variety of strategies for expansion of the 
      NMDP Registry. Cost-effectiveness calculations incorporated donor unavailability 
      and other barriers to transplantation. RESULTS: At current recruitment rates, the 
      probability of an available HLA-A,B,DRB1 matched donor is projected to increase 
      from 27% to 34%; 45% to 54%; 75% to 79%; and 48% to 55%, for blacks, 
      Asians/Pacific Islanders, whites and Hispanics, respectively, by the year 2007. 
      Substantial increases in minority recruitment would have only modest impacts on 
      these projections. These projections are heavily affected by donor availability 
      rates, which are less than 50% for minority volunteers. CONCLUSIONS: Continued 
      recruitment of additional volunteers can improve the likelihood of finding an 
      HLA-matched donor, but will still leave significant numbers of patients of all 
      racial/ethnic groups without a match. Efforts to improve donor availability 
      (especially among minorities) and to increase the number of patients with access 
      to the NMDP Registry may prove to be more cost-effective means of increasing 
      transplants.
FAU - Kollman, Craig
AU  - Kollman C
AD  - National Marrow Donor Program, Minneapolis, MN, USA. ckollman@jaeb.org
FAU - Abella, Esteban
AU  - Abella E
FAU - Baitty, Robert L
AU  - Baitty RL
FAU - Beatty, Patrick G
AU  - Beatty PG
FAU - Chakraborty, Ranajit
AU  - Chakraborty R
FAU - Christiansen, Cindy L
AU  - Christiansen CL
FAU - Hartzman, Robert J
AU  - Hartzman RJ
FAU - Hurley, Carolyn Katovich
AU  - Hurley CK
FAU - Milford, Edgar
AU  - Milford E
FAU - Nyman, John A
AU  - Nyman JA
FAU - Smith, Thomas J
AU  - Smith TJ
FAU - Switzer, Galen E
AU  - Switzer GE
FAU - Wada, Randal K
AU  - Wada RK
FAU - Setterholm, Michelle
AU  - Setterholm M
LA  - eng
GR  - HS 240-97-0036/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
SB  - IM
MH  - Genetics, Population
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Public Policy
MH  - Registries/*statistics & numerical data
MH  - Tissue Donors/*statistics & numerical data
MH  - United States
EDAT- 2004/07/17 05:00
MHDA- 2004/08/18 05:00
CRDT- 2004/07/17 05:00
PHST- 2004/07/17 05:00 [pubmed]
PHST- 2004/08/18 05:00 [medline]
PHST- 2004/07/17 05:00 [entrez]
AID - 00007890-200407150-00015 [pii]
AID - 10.1097/01.tp.0000132327.40702.97 [doi]
PST - ppublish
SO  - Transplantation. 2004 Jul 15;78(1):89-95. doi: 10.1097/01.tp.0000132327.40702.97.