PMID- 15257146
OWN - NLM
STAT- MEDLINE
DCOM- 20041021
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 15
IP  - 11
DP  - 2004 Aug 6
TI  - Tuberoinfundibular peptide of 39 residues decreases pain-related affective 
      behavior.
PG  - 1779-82
AB  - Tuberoinfundibular peptide of 39 residues (TIP39) is a recently identified 
      parathyroid hormone 2 receptor ligand. Their CNS distributions suggest potential 
      involvement in neuroendocrine, limbic and sensory processing functions. Herein we 
      investigate the analgesic and antinociceptive actions of brain delivery of TIP39 
      in adult male rats. Intracerebroventricular (i.c.v.) TIP39 did not change 
      hot-plate paw withdrawal latency or formalin test behavioral responses. TIP39 
      partially reversed tactile withdrawal hypersensitivity following carageenan 
      administration. In the place/escape avoidance paradigm (PEAP), which evaluates 
      affective components of responses to noxious stimuli by presenting a choice 
      between a naturally preferred environment paired with stimulation of a 
      carrageenan sensitized paw and a less preferred environment paired with 
      stimulation of a less sensitive paw, TIP39 decreased the apparent aversiveness of 
      sensitive paw stimulation. Because acute sensory thresholds were unaffected by 
      TIP39, and the effects of i.c.v. TIP39 were opposite in direction from previously 
      described effects of intrathecal TIP39, this suggests that TIP39 may modulate an 
      affective component of nociception within the brain.
FAU - LaBuda, Christopher J
AU  - LaBuda CJ
AD  - Laboratory of Genetics, National Institute of Mental Health, Bldg. 36/Rm. 3D06, 
      36 Convent Dr. MSC 4094, Bethesda, MD 20892-4094, USA.
FAU - Usdin, Ted B
AU  - Usdin TB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Neuropeptides)
RN  - 0 (tuberoinfundibular peptide 39)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/*drug effects/physiology
MH  - Brain/drug effects
MH  - Male
MH  - Neuropeptides/pharmacology/*therapeutic use
MH  - Pain/*drug therapy/psychology
MH  - Pain Measurement/*drug effects/methods
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2004/07/17 05:00
MHDA- 2004/10/22 09:00
CRDT- 2004/07/17 05:00
PHST- 2004/07/17 05:00 [pubmed]
PHST- 2004/10/22 09:00 [medline]
PHST- 2004/07/17 05:00 [entrez]
AID - 00001756-200408060-00018 [pii]
AID - 10.1097/01.wnr.0000134849.63755.15 [doi]
PST - ppublish
SO  - Neuroreport. 2004 Aug 6;15(11):1779-82. doi: 10.1097/01.wnr.0000134849.63755.15.