PMID- 15257881
OWN - NLM
STAT- MEDLINE
DCOM- 20041214
LR  - 20221207
IS  - 0949-2321 (Print)
IS  - 0949-2321 (Linking)
VI  - 9
IP  - 5
DP  - 2004 May 28
TI  - Cardiovascular risk factors and probability for cardiovascular events in 
      HIV-infected patients - part III: age differences.
PG  - 267-72
AB  - OBJECTIVE: In recent years, concerns have been growing about an elevated rate of 
      cardiovascular diseases in HIV-infected patients due to side effects of 
      antiretroviral therapy. The present study analyses the cardiovascular risk 
      profile and the probability of cardiovascular events with regard to the age of 
      HIV-infected patients. METHODS: Cardiovascular risk factors of 309 HIV-infected 
      adults were analysed. Patients were divided into four groups: 18-30 years (group 
      1), 31-40 years (group 2), 41-50 years (group 3), > 50 years (group 4). Overall 
      10-years probability for cardiovascular events was evaluated by the Framingham 
      algorithm. RESULTS: Differences between the groups were detected in 
      cardiovascular risk factors including changes in lipid- and glucose metabolism. 
      Lipid values increased with elevated age, such as total cholesterol concentration 
      (Mean +/- SEM in group 1 vs. group 4: 4.71 +/- 0.20 to 6.36 +/- 0.21 mmol/L, p < 
      0.05), LDL-cholesterol concentration (2.86 +/- 0.17 vs. 4.17 +/- 0.21 mmol/L, p < 
      0.05) and triglyceride concentration (1.56 +/- 0.14 vs. 3.48 +/- 0.40 mmol/L, p < 
      0.05). HDL-cholesterol concentration did not show a significant difference (1.15 
      +/- 0.03 mmol/L). Glucose concentration increased with elevated age in 
      HIV-infected patients (5.28 +/- 0.19 vs. 6.46 +/- 0.24 mmHg, p < 0.05), but there 
      was no significant difference in HbA1c - concentration, blood pressure and 
      smoking rate between the groups. The overall 10-years probability for 
      cardiovascular events was higher in group 1 (median: 1.9%) than in group 4 
      (20.5%; p < 0.01). CONCLUSIONS: The risk of cardiovascular events is related to 
      the age in HIV-infected patients. Therefore, an increased duration of life due to 
      a more effective antiretroviral therapy will have a significant impact on the 
      rate of cardiovascular events in this patient population. In the future, further 
      increase of cardiovascular events in HIV-infected patients may be expected.
FAU - Neumann, Till
AU  - Neumann T
AD  - Department of Cardiology, University of Duisburg-Essen, Medical School, 
      Hufelandstr. 55, D-45122 Essen, Germany. till.neumann@uni-essen.de
FAU - Woiwod, T
AU  - Woiwod T
FAU - Neumann, A
AU  - Neumann A
FAU - Miller, M
AU  - Miller M
FAU - Von Birgelen, C
AU  - Von Birgelen C
FAU - Volbracht, L
AU  - Volbracht L
FAU - Esser, S
AU  - Esser S
FAU - Brockmeyer, N
AU  - Brockmeyer N
FAU - Gerken, G
AU  - Gerken G
FAU - Erbel, R
AU  - Erbel R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Med Res
JT  - European journal of medical research
JID - 9517857
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Algorithms
MH  - Anti-HIV Agents/therapeutic use
MH  - Antiretroviral Therapy, Highly Active
MH  - Blood Glucose/analysis
MH  - Blood Pressure
MH  - Cardiovascular Diseases/diagnosis/*etiology
MH  - Cholesterol/blood
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - HIV Infections/blood/*complications/drug therapy
MH  - Hemoglobinuria/metabolism
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Probability
MH  - Risk Factors
MH  - Smoking
EDAT- 2004/07/20 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/07/20 05:00
PHST- 2004/07/20 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/07/20 05:00 [entrez]
PST - ppublish
SO  - Eur J Med Res. 2004 May 28;9(5):267-72.