PMID- 1525829
OWN - NLM
STAT- MEDLINE
DCOM- 19921019
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 70
IP  - 6
DP  - 1992 Sep 18
TI  - deadpan, an essential pan-neural gene encoding an HLH protein, acts as a 
      denominator in Drosophila sex determination.
PG  - 911-22
AB  - In Drosophila, sex is determined by the X:A ratio. One major numerator element on 
      the X chromosome is sisterless-b (sis-b), also called scute, which encodes an 
      HLH-type transcription factor. We report here that an essential pan-neural gene, 
      the autosomal HLH gene deadpan (dpn), acts as a denominator element. As revealed 
      by dosage-dependent dominant interactions, males die with too high a ratio of sc+ 
      to dpn+, caused by misexpression of Sex lethal (Sxl) in embryos, and females die 
      with too low a ratio of sc+ to dpn+, because of altered embryonic Sxl expression. 
      In addition, we found that the HLH gene extramacrochaetae (emc), like 
      daughterless (da), is needed maternally for proper communication of the X:A 
      ratio, thus supporting the idea that a set of HLH genes comprises a functional 
      cassette that makes a sensitive and stable genetic switch used in both neural 
      determination and sex determination.
FAU - Younger-Shepherd, S
AU  - Younger-Shepherd S
AD  - Howard Hughes Medical Institute, University of California, San Francisco 94143.
FAU - Vaessin, H
AU  - Vaessin H
FAU - Bier, E
AU  - Bier E
FAU - Jan, L Y
AU  - Jan LY
FAU - Jan, Y N
AU  - Jan YN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
SB  - IM
GS  - Sxl
GS  - da
GS  - dpn
GS  - emc
GS  - sc
GS  - sis-a
GS  - sis-b/sc
MH  - Animals
MH  - Chromosome Deletion
MH  - Dosage Compensation, Genetic
MH  - Drosophila/embryology/*genetics
MH  - Female
MH  - Genes, Lethal
MH  - Male
MH  - Multigene Family
MH  - Nervous System/embryology
MH  - Sex Differentiation/*genetics
MH  - Suppression, Genetic
EDAT- 1992/09/18 00:00
MHDA- 1992/09/18 00:01
CRDT- 1992/09/18 00:00
PHST- 1992/09/18 00:00 [pubmed]
PHST- 1992/09/18 00:01 [medline]
PHST- 1992/09/18 00:00 [entrez]
AID - 0092-8674(92)90242-5 [pii]
AID - 10.1016/0092-8674(92)90242-5 [doi]
PST - ppublish
SO  - Cell. 1992 Sep 18;70(6):911-22. doi: 10.1016/0092-8674(92)90242-5.