PMID- 15258975
OWN - NLM
STAT- MEDLINE
DCOM- 20050208
LR  - 20081121
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 74
IP  - 1
DP  - 2004 Sep
TI  - Prevalence and distribution of HSV-1, VZV, and HHV-6 in human cranial nerve 
      nuclei III, IV, VI, VII, and XII.
PG  - 102-6
AB  - The etiology of idiopathic cranial nerve palsies often remains unresolved. It has 
      been hypothesised that viral reactivation of herpesviruses in the corresponding 
      nuclei in the brainstem is the cause. We investigated the distribution of herpes 
      simplex virus type 1 (HSV-1) and varicella zoster virus (VZV) in nuclei that are 
      associated with peripheral sensory ganglia [oculomotor (nIII), facial (nVII) 
      nuclei] and in nuclei that are not associated with peripheral sensory ganglia 
      [trochlear (nIV), abducens (nVI), and hypoglossal (nXII) nuclei] of five human 
      brainstems. Samples of the cranial nerve nuclei and adjacent control tissue were 
      taken from histological sections after precise identification of every single 
      nucleus and control tissue. DNA and RNA amplification methods were used to 
      determine the prevalence and distribution of HSV-1 and VZV. The distribution of 
      human herpes virus type 6 (HHV-6) was also determined and served as a control, 
      since HHV-6 infection has never been associated with idiopathic cranial nerve 
      palsies. HSV-1 was distributed at random in all cranial nerve nuclei and control 
      tissue, whereas VZV DNA was not detected in any of the samples examined. 
      Surprisingly, HHV-6 was present in almost all samples where HSV-1 was also 
      present, however, the latency associated transcript (LAT) of HSV-1 was not found 
      in any of the samples positive for HSV-1 DNA. The absence of LAT in the samples 
      positive for HSV-1 and the distribution of HSV-1 and HHV-6 do not support the 
      hypothesis that idiopathic cranial nerve palsies result from viral reactivation 
      in the brainstem nuclei.
FAU - Theil, Diethilde
AU  - Theil D
AD  - Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, 
      Munich, Germany. dtheil@brain.nefo.uni-muenchen.de
FAU - Horn, Anja K E
AU  - Horn AK
FAU - Derfuss, Tobias
AU  - Derfuss T
FAU - Strupp, Michael
AU  - Strupp M
FAU - Arbusow, Viktor
AU  - Arbusow V
FAU - Brandt, Thomas
AU  - Brandt T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (DNA, Viral)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Viral)
RN  - 0 (Viral Proteins)
RN  - 0 (latency associated transcript, herpes simplex virus-1)
SB  - IM
MH  - Abducens Nerve/virology
MH  - Adult
MH  - Aged
MH  - Brain Stem/*virology
MH  - Cranial Nerve Diseases/etiology
MH  - Cranial Nerves/*virology
MH  - DNA, Viral/analysis
MH  - Facial Nerve/virology
MH  - Female
MH  - Ganglia/virology
MH  - Herpesvirus 1, Human/*isolation & purification
MH  - Herpesvirus 3, Human/*isolation & purification
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - Hypoglossal Nerve/virology
MH  - Male
MH  - MicroRNAs
MH  - Nucleic Acid Amplification Techniques
MH  - Oculomotor Nerve/virology
MH  - RNA, Viral/analysis
MH  - Trochlear Nerve/virology
MH  - Viral Proteins/genetics
MH  - Virus Activation
EDAT- 2004/07/20 05:00
MHDA- 2005/02/09 09:00
CRDT- 2004/07/20 05:00
PHST- 2004/07/20 05:00 [pubmed]
PHST- 2005/02/09 09:00 [medline]
PHST- 2004/07/20 05:00 [entrez]
AID - 10.1002/jmv.20152 [doi]
PST - ppublish
SO  - J Med Virol. 2004 Sep;74(1):102-6. doi: 10.1002/jmv.20152.