PMID- 15258997
OWN - NLM
STAT- MEDLINE
DCOM- 20040920
LR  - 20071115
IS  - 0022-3417 (Print)
IS  - 0022-3417 (Linking)
VI  - 203
IP  - 4
DP  - 2004 Aug
TI  - Homogeneous immunophenotype and paucity of secondary genomic aberrations are 
      distinctive features of endemic but not of sporadic Burkitt's lymphoma and 
      diffuse large B-cell lymphoma with MYC rearrangement.
PG  - 940-5
AB  - The present study has compared immunohistological marker expression profiles and 
      genomic imbalances in seven African endemic Burkitt's lymphomas (eBLs) with those 
      in ten European B-cell lymphomas with MYC rearrangement as shown by fluorescence 
      in situ hybridization (FISH) analysis. eBLs showed a typical histomorphology and 
      a homogeneous immuno-profile: CD10+, CD38+, CD77+, bcl-2-, and IgM+. Epstein-Barr 
      virus (EBV) DNA was present in all cases. On comparative genomic hybridization 
      (CGH), only three out of six eBLs showed imbalances (median number of imbalances 
      = 2), with gains on chromosome 17 in two eBLs. The European lymphomas were all 
      highly proliferating, with a Ki-67 index of at least 90%, and included seven with 
      morphology typical of sporadic Burkitt's lymphoma (sBL) and three immunoblastic 
      diffuse large B-cell lymphomas with MYC rearrangement (MYCre+DLBCL). In contrast 
      to eBL, the immuno-profiles of the European lymphomas were less homogeneous and 
      inconsistent for CD10, CD38, CD77, IgM and bcl-2 expression. EBV DNA was not 
      detected. In five of seven sBLs, CGH showed a higher number of imbalances (median 
      = 6), with recurrent gains on chromosome 1q (3/7) and losses on 12q and 17p 
      (2/7), whereas all three MYCre+DLBCLs had fewer imbalances (median = 4), with 
      gains on 17q in two of three lymphomas. It is concluded that eBL has a 
      homogeneous immunohistology and few secondary genomic aberrations, whereas 
      MYC-rearranged and highly proliferating European B-cell lymphomas are a 
      heterogeneous group that includes sBL and a subgroup of diffuse large B-cell 
      lymphomas.
CI  - Copyright 2004 Pathological Society of Great Britain and Ireland
FAU - Barth, Thomas F E
AU  - Barth TF
AD  - Institut fur Pathologie des Universitatsklinikums Ulm, Albert-Einstein-Allee 11, 
      D-89081 Ulm, Germany.
FAU - Muller, Silja
AU  - Muller S
FAU - Pawlita, Michael
AU  - Pawlita M
FAU - Siebert, Reiner
AU  - Siebert R
FAU - Rother, Josef U
AU  - Rother JU
FAU - Mechtersheimer, Gunhild
AU  - Mechtersheimer G
FAU - Kitinya, James
AU  - Kitinya J
FAU - Bentz, Martin
AU  - Bentz M
FAU - Moller, Peter
AU  - Moller P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Burkitt Lymphoma/genetics/*immunology/pathology/virology
MH  - Cell Division
MH  - Child
MH  - Child, Preschool
MH  - *Chromosome Aberrations
MH  - Endemic Diseases
MH  - Female
MH  - Gene Rearrangement
MH  - Genes, myc/*genetics
MH  - Herpesvirus 4, Human/isolation & purification
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Large B-Cell, Diffuse/genetics/*immunology/pathology/virology
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Hybridization
EDAT- 2004/07/20 05:00
MHDA- 2004/09/21 05:00
CRDT- 2004/07/20 05:00
PHST- 2004/07/20 05:00 [pubmed]
PHST- 2004/09/21 05:00 [medline]
PHST- 2004/07/20 05:00 [entrez]
AID - 10.1002/path.1596 [doi]
PST - ppublish
SO  - J Pathol. 2004 Aug;203(4):940-5. doi: 10.1002/path.1596.