PMID- 15259763
OWN - NLM
STAT- MEDLINE
DCOM- 20040930
LR  - 20190901
IS  - 0015-5632 (Print)
IS  - 0015-5632 (Linking)
VI  - 49
IP  - 3
DP  - 2004
TI  - Sequence similarities of protein kinase substrates and inhibitors with 
      immunoglobulins and model immunoglobulin homologue: cell adhesion molecule from 
      the living fossil sponge Geodia cydonium. Mapping of coherent database 
      similarities and implications for evolution of CDR1 and hypermutation.
PG  - 219-46
AB  - Sequences of immunoglobulin (Ig) domains of adhesive molecule GSAMS from the 
      living fossil sponge Geodia cydonium were compared with the important motif of 
      peptide protein kinase substrates and inhibitors (PKSI), detail PKSI sequences, 
      and a common template sequence, derived from structures determined previously. We 
      found the site-restricted sequence similarities to these peptide sequences 
      predominantly in the GSAM Ig1 domain of GSAMS in the domain region related to 
      corresponding Ig similarities detected earlier. Additional sequence block-related 
      analysis revealed the presence of CDR1-like segments within PKSI-related regions 
      and resulted in the detection of increased numbers of hypermutation motifs just 
      in the CDR1-like segment of GSAM Ig1 (GSAM(cdrl.1)). In the following database 
      searches with PKSI-related regions and GSAM(cdr1.1) we looked for: (i) peptide 
      similarities present in the context of Ig domains or related structures in a 
      large range of species from Archaea to Vertebrata, and (ii) some special 
      nucleotide similarities.
FAU - Kubrycht, J
AU  - Kubrycht J
AD  - Center of Occupational Diseases, National Institute of Public Health, 100 42 
      Prague, Czechia. kubjar@szu.cz
FAU - Borecky, J
AU  - Borecky J
FAU - Soucek, P
AU  - Soucek P
FAU - Jezek, P
AU  - Jezek P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Folia Microbiol (Praha)
JT  - Folia microbiologica
JID - 0376757
RN  - 0 (Amino Acids)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Immunoglobulins)
RN  - 0 (Protein Kinase Inhibitors)
RN  - EC 2.7.- (Protein Kinases)
SB  - IM
EIN - Folia Microbiol (Praha). 2004;49(5):631-2
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Amino Acids/analysis
MH  - Animals
MH  - Biological Evolution
MH  - Cell Adhesion Molecules/chemistry/*genetics
MH  - Databases, Factual
MH  - Fossils
MH  - Immunoglobulins/genetics/*metabolism
MH  - Porifera/*genetics
MH  - *Protein Kinase Inhibitors
MH  - Protein Kinases/*metabolism
MH  - Sequence Alignment
MH  - *Sequence Homology, Amino Acid
MH  - Somatic Hypermutation, Immunoglobulin
EDAT- 2004/07/21 05:00
MHDA- 2004/10/01 05:00
CRDT- 2004/07/21 05:00
PHST- 2004/07/21 05:00 [pubmed]
PHST- 2004/10/01 05:00 [medline]
PHST- 2004/07/21 05:00 [entrez]
AID - 10.1007/BF02931038 [doi]
PST - ppublish
SO  - Folia Microbiol (Praha). 2004;49(3):219-46. doi: 10.1007/BF02931038.