PMID- 15262438
OWN - NLM
STAT- MEDLINE
DCOM- 20040824
LR  - 20071115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 152
IP  - 2
DP  - 2004 Jul 15
TI  - Trisomy 4 as the sole cytogenetic abnormality in a patient with T-cell acute 
      lymphoblastic leukemia.
PG  - 158-62
AB  - Trisomies as sole cytogenetic abnormalities are extremely rare in acute 
      lymphoblastic leukemia (ALL). We describe here the clinical features and 
      immunophenotyping, cytogenetic, and fluorescence in situ hybridization (FISH) 
      findings in a T-cell ALL patient with trisomy 4 as the sole cytogenetic 
      abnormality. The leukemic clone was positive for CD2, CD7, CD34, and terminal 
      deoxynucleotidyl transferase (TdT); CD13 was weakly expressed. Data on the 
      tracking of the leukemic clone with immunophenotyping, cytogenetic, and FISH 
      studies are discussed. The present case is compared with the three previous 
      reported cases of trisomy 4 in ALL. Due to the rarity of this cytogenetic 
      abnormality, its prognostic significance in ALL remains unclear.
FAU - Gupta, Vikas
AU  - Gupta V
AD  - Department of Medical Oncology and Hematology, Princess Margaret 
      Hospital-University Health Network, University of Toronto, 610 University Avenue, 
      Toronto, ON M5G 2M9, Canada. vikas.gupta@uhn.on.ca
FAU - Chun, Kathy
AU  - Chun K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adolescent
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 4
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia-Lymphoma, Adult T-Cell/*genetics
MH  - Male
MH  - Prognosis
MH  - *Trisomy
RF  - 24
EDAT- 2004/07/21 05:00
MHDA- 2004/08/25 05:00
CRDT- 2004/07/21 05:00
PHST- 2003/09/15 00:00 [received]
PHST- 2003/11/24 00:00 [revised]
PHST- 2003/11/25 00:00 [accepted]
PHST- 2004/07/21 05:00 [pubmed]
PHST- 2004/08/25 05:00 [medline]
PHST- 2004/07/21 05:00 [entrez]
AID - S0165460803005065 [pii]
AID - 10.1016/j.cancergencyto.2003.11.014 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2004 Jul 15;152(2):158-62. doi: 
      10.1016/j.cancergencyto.2003.11.014.