PMID- 15263029
OWN - NLM
STAT- MEDLINE
DCOM- 20040824
LR  - 20181113
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 200
IP  - 2
DP  - 2004 Jul 19
TI  - Unique clinical and pathological features in HLA-DRB1*0401-restricted MBP 
      111-129-specific humanized TCR transgenic mice.
PG  - 223-34
AB  - Amino acid residues 111-129 represent an immunodominant epitope of myelin basic 
      protein (MBP) in humans with human leukocyte antigen (HLA)-DRB1*0401 allele(s). 
      The MBP 111-129-specific T cell clone MS2-3C8 was repeatedly isolated from a 
      patient with multiple sclerosis (MS), suggesting an involvement of MS2-3C8 T 
      cells in the pathogenesis. To address the pathogenic potential of the MS2-3C8 T 
      cell clone, we generated transgenic (Tg) mice expressing its T cell receptor and 
      restriction element, HLA-DRB1*0401, to examine the pathogenic characteristics of 
      MS2-3C8 Tg T cells by adoptive transfer into HLA-DRB1*0401 Tg mice. In addition 
      to the ascending paralysis typical of experimental autoimmune encephalomyelitis, 
      mice displayed dysphagia due to restriction in jaw and tongue movements and 
      abnormal gait. In accordance with the clinical phenotype, infiltrates of MS2-3C8 
      Tg T cells and inflammatory lesions were predominantly located in the brainstem 
      and the cranial nerve roots in addition to the spinal cord and spinal nerve 
      roots. Together, these data suggest a pathogenic role of MBP-specific T cells in 
      inflammatory demyelination within the brainstem and cranial nerve roots during 
      the progression of MS. This notion may help to explain the clinical and 
      pathological heterogeneity of MS.
FAU - Quandt, Jacqueline A
AU  - Quandt JA
AD  - Department of Neurology, Robert Wood Johnson Medical School, UMDNJ, 683 Hoes Ln., 
      Piscataway, NJ 08854, USA.
FAU - Baig, Mirza
AU  - Baig M
FAU - Yao, Karen
AU  - Yao K
FAU - Kawamura, Kazuyuki
AU  - Kawamura K
FAU - Huh, Jaebong
AU  - Huh J
FAU - Ludwin, Samuel K
AU  - Ludwin SK
FAU - Bian, Hong-Jin
AU  - Bian HJ
FAU - Bryant, Mark
AU  - Bryant M
FAU - Quigley, Laura
AU  - Quigley L
FAU - Nagy, Zoltan A
AU  - Nagy ZA
FAU - McFarland, Henry F
AU  - McFarland HF
FAU - Muraro, Paolo A
AU  - Muraro PA
FAU - Martin, Roland
AU  - Martin R
FAU - Ito, Kouichi
AU  - Ito K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Cytokines)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04:01 antigen)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Separation
MH  - Cytokines/biosynthesis
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Encephalomyelitis, Autoimmune, Experimental/metabolism
MH  - Flow Cytometry
MH  - HLA-DR Antigens/*metabolism
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Immunohistochemistry
MH  - Inflammation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Mice, Transgenic
MH  - Molecular Sequence Data
MH  - Multiple Sclerosis/metabolism
MH  - Phenotype
MH  - Receptors, Antigen, T-Cell/*genetics/metabolism
MH  - Time Factors
PMC - PMC2212014
EDAT- 2004/07/21 05:00
MHDA- 2004/08/25 05:00
PMCR- 2005/01/19
CRDT- 2004/07/21 05:00
PHST- 2004/07/21 05:00 [pubmed]
PHST- 2004/08/25 05:00 [medline]
PHST- 2004/07/21 05:00 [entrez]
PHST- 2005/01/19 00:00 [pmc-release]
AID - jem.20030994 [pii]
AID - 20030994 [pii]
AID - 10.1084/jem.20030994 [doi]
PST - ppublish
SO  - J Exp Med. 2004 Jul 19;200(2):223-34. doi: 10.1084/jem.20030994.