PMID- 15264231
OWN - NLM
STAT- MEDLINE
DCOM- 20041004
LR  - 20131121
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 77
IP  - 4
DP  - 2004 Aug 15
TI  - Pressor effects of electrical stimulation of medial prefrontal cortex in 
      unanesthetized rats.
PG  - 613-20
AB  - The medial prefrontal cortex (MPFC) is involved in central nervous system 
      (CNS)-mediated cardiovascular modulation. We compared the cardiovascular effects 
      of electrical stimulation (EE) of the MPFC in unanesthetized rats to those 
      observed after stimulation of the same area in urethane-anesthetized rats. 
      Electrical stimulation (35, 106, 177, 247, 318, and 389 microA rms/10 sec, 60-Hz 
      sine wave) of the MPFC of urethane-anesthetized rats caused depressor responses 
      of stimulus-related intensity. The cardiovascular response to electrical 
      stimulation of the MPFC in unanesthetized rats was characterized by 
      stimulus-related pressor responses. No significant heart rate changes were 
      observed during the EE period in any case. The pressor response to electrical 
      stimulation (106 microA rms/10 sec, 60-Hz sine wave) of the MPFC was not affected 
      by intravenous pretreatment with the vasopressin antagonist dTyr(CH(2))(5)(Me)AVP 
      (50 microg/kg, intravenously), by hypophysectomy, or by intravenous pretreatment 
      with the angiotensin II antagonist losartan (1 mg/kg, intravenously). The pressor 
      response was blocked by intravenous pretreatment with the ganglionic blocker 
      mecamylamine (2 mg/kg, intravenously) but was not affected by adrenal 
      demedullation, thus suggesting involvement of the neural component of the 
      sympathetic nervous system without a major involvement of its hormonal component. 
      Our results confirmed the occurrence of depressor responses after electrical 
      stimulation of the MPFC in urethane-anesthetized rats and evidenced that only 
      pressor responses are observed after its stimulation in unanesthetized rats. The 
      fact that the pressor response to the stimulation of the MPFC was blocked by a 
      ganglioplegic suggests that the MPFC has functional excitatory actions over the 
      sympathetic nervous system.
CI  - Copyright 2004 Wiley-Liss, Inc.
FAU - Tavares, Rodrigo Fiacadori
AU  - Tavares RF
AD  - Department of Pharmacology, School of Medicine of Ribeirao Preto, University of 
      Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
FAU - Antunes-Rodrigues, Jose
AU  - Antunes-Rodrigues J
FAU - de Aguiar Correa, Fernando Morgan
AU  - de Aguiar Correa FM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 11000-17-2 (Vasopressins)
RN  - 11128-99-7 (Angiotensin II)
RN  - 3IN71E75Z5 (Urethane)
RN  - 6EE945D3OK (Mecamylamine)
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - Adrenal Medulla/injuries/innervation/physiology
MH  - Angiotensin II/antagonists & inhibitors/metabolism
MH  - Animals
MH  - Autonomic Pathways/drug effects/*physiology
MH  - Blood Pressure/drug effects/*physiology
MH  - Denervation
MH  - Efferent Pathways/drug effects/*physiology
MH  - Electric Stimulation
MH  - Electrodes, Implanted
MH  - Ganglia, Sympathetic/drug effects/physiology
MH  - Losartan/pharmacology
MH  - Male
MH  - Mecamylamine/pharmacology
MH  - Prefrontal Cortex/cytology/drug effects/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Sympathetic Nervous System/drug effects/*physiology
MH  - Urethane/pharmacology
MH  - Vasoconstriction/drug effects/*physiology
MH  - Vasopressins/antagonists & inhibitors
MH  - Wakefulness/physiology
EDAT- 2004/07/21 05:00
MHDA- 2004/10/05 09:00
CRDT- 2004/07/21 05:00
PHST- 2004/07/21 05:00 [pubmed]
PHST- 2004/10/05 09:00 [medline]
PHST- 2004/07/21 05:00 [entrez]
AID - 10.1002/jnr.20195 [doi]
PST - ppublish
SO  - J Neurosci Res. 2004 Aug 15;77(4):613-20. doi: 10.1002/jnr.20195.