PMID- 15265515
OWN - NLM
STAT- MEDLINE
DCOM- 20050204
LR  - 20131121
IS  - 0928-0987 (Print)
IS  - 0928-0987 (Linking)
VI  - 22
IP  - 5
DP  - 2004 Aug
TI  - Comparative therapeutic efficacy of a novel lyophilized amphotericin B 
      lecithin-based oil-water microemulsion and deoxycholate-amphotericin B in 
      immunocompetent and neutropenic mice infected with Candida albicans.
PG  - 451-8
AB  - The in vivo efficacy of a new amphotericin B (AmB) oil-in-water lecithin-based 
      microemulsion delivery system (M-AmB) compared to deoxycholate-AmB (D-AmB) was 
      studied in an immunocompetent and neutropenic murine model of systemic 
      candidiasis. D-AmB was administered at the maximum tolerated dose of 1 mg/kg 
      whereas M-AmB was given at the doses of 1, 2 and 3 mg/kg; doses were well 
      tolerated due to their reduced toxicity. Both formulations were administered 24, 
      48 and 72 h after infection in immunocompetent mice, and 2, 6 and 24 h after 
      infection in neutropenic mice. Kaplan-Meier survival curves showed that the M-AmB 
      treated group had a better survival time than infected mice without treatment 
      used as a control group (P = 4.66 x 10(-6)), and the Mann-Whitney W statistical 
      test indicated that it reduced the percentage of mortality and fungal load in the 
      most representative organs. This new formulation is a designed competitor which 
      has proved to present better results than D-AmB in an established infection not 
      only in immunocompetent but in neutropenic mice as well.
FAU - Brime, Begona
AU  - Brime B
AD  - Department of Pharmacy and Pharmaceutical Technology, Complutense University of 
      Madrid, 28040 Madrid, Spain.
FAU - Molero, Gloria
AU  - Molero G
FAU - Frutos, Paloma
AU  - Frutos P
FAU - Frutos, Gloria
AU  - Frutos G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharm Sci
JT  - European journal of pharmaceutical sciences : official journal of the European 
      Federation for Pharmaceutical Sciences
JID - 9317982
RN  - 0 (Emulsions)
RN  - 0 (Phosphatidylcholines)
RN  - 005990WHZZ (Deoxycholic Acid)
RN  - 7XU7A7DROE (Amphotericin B)
SB  - IM
MH  - Amphotericin B/chemistry/pharmacology/*therapeutic use
MH  - Animals
MH  - Candidiasis/*drug therapy/immunology
MH  - Chemistry, Pharmaceutical
MH  - Deoxycholic Acid/chemistry/pharmacology/therapeutic use
MH  - Emulsions
MH  - Freeze Drying
MH  - Immunocompetence/drug effects/physiology
MH  - Male
MH  - Mice
MH  - Neutropenia/*drug therapy/immunology
MH  - Phosphatidylcholines/chemistry/pharmacology/*therapeutic use
EDAT- 2004/07/22 05:00
MHDA- 2005/02/05 09:00
CRDT- 2004/07/22 05:00
PHST- 2003/08/29 00:00 [received]
PHST- 2004/04/28 00:00 [revised]
PHST- 2004/04/29 00:00 [accepted]
PHST- 2004/07/22 05:00 [pubmed]
PHST- 2005/02/05 09:00 [medline]
PHST- 2004/07/22 05:00 [entrez]
AID - S0928098704001198 [pii]
AID - 10.1016/j.ejps.2004.04.008 [doi]
PST - ppublish
SO  - Eur J Pharm Sci. 2004 Aug;22(5):451-8. doi: 10.1016/j.ejps.2004.04.008.