PMID- 15266540
OWN - NLM
STAT- MEDLINE
DCOM- 20041130
LR  - 20220219
IS  - 1469-493X (Electronic)
IS  - 1361-6137 (Linking)
VI  - 2004
IP  - 3
DP  - 2004
TI  - Hyperbaric oxygen therapy for thermal burns.
PG  - CD004727
LID - CD004727
AB  - BACKGROUND: Hyperbaric oxygen therapy (HBOT) consists of intermittently 
      administering 100% oxygen at pressures greater than 1 atmosphere in a pressure 
      vessel. This technology has been used to treat a variety of disease states and 
      has been described as helping patients who have sustained burns. OBJECTIVES: The 
      aim of this review was to assess the evidence for the benefit of hyperbaric 
      oxygen treatment (HBOT) for the treatment of thermal burns. SEARCH STRATEGY: We 
      searched the Cochrane Controlled Trials Register (The Cochrane Library, Issue 3, 
      2002), MEDLINE (Ovid 1966 to November Week 2, 2003), CINAHL (Ovid 1982 to 
      December Week 2 2003), EMBASE (Ovid 1980 to September 2003), DORCTHIM (Database 
      of Randomised Controlled Trials in Hyperbaric Medicine) from inception to 2003, 
      and reference lists of articles. SELECTION CRITERIA: We included all randomised 
      controlled trials that compared the effect of HBOT with no HBOT (no treatment or 
      sham). DATA COLLECTION AND ANALYSIS: Two authors using standardised forms 
      extracted the data independently. Each trial was assessed for internal validity 
      with differences resolved by discussion. Data was extracted and entered into 
      RevMan 4.2.3. MAIN RESULTS: Four randomised controlled trials were identified, of 
      which two satisfied the inclusion criteria. The trials were of poor 
      methodological quality. As a result, it was difficult to have confidence in the 
      individual results and it would not have been appropriate to attempt to pool the 
      data. One trial reported no difference in length of stay, mortality, or number of 
      surgeries between the control and HBO-treated groups once these variables were 
      adjusted for the patient's condition. The second trial reported mean healing 
      times that were shorter in patients exposed to HBOT (mean: 19.7 days versus 43.8 
      days). REVIEWERS' CONCLUSIONS: This systematic review has not found sufficient 
      evidence to support or refute the effectiveness of HBOT for the management of 
      thermal burns. Evidence from the two randomised controlled trials is insufficient 
      to provide clear guidelines for practice. Further research is needed to better 
      define the role of HBOT in the treatment of thermal burns.
FAU - Villanueva, E
AU  - Villanueva E
FAU - Bennett, M H
AU  - Bennett MH
FAU - Wasiak, J
AU  - Wasiak J
FAU - Lehm, J P
AU  - Lehm JP
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Cochrane Database Syst Rev
JT  - The Cochrane database of systematic reviews
JID - 100909747
SB  - IM
UOF - doi: 10.1002/14651858.CD004727
MH  - Burns/*therapy
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - Randomized Controlled Trials as Topic
PMC - PMC8846294
COIS- None known. 
 The authors of this article are responsible for its contents. 
      Statements contained herein should be constructed as reflecting the views of the 
      authors and not of the agencies or organisations involved in the work.
EDAT- 2004/07/22 05:00
MHDA- 2004/12/16 09:00
PMCR- 2005/04/19
CRDT- 2004/07/22 05:00
PHST- 2004/07/22 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/07/22 05:00 [entrez]
PHST- 2005/04/19 00:00 [pmc-release]
AID - CD004727.pub2 [pii]
AID - 10.1002/14651858.CD004727.pub2 [doi]
PST - ppublish
SO  - Cochrane Database Syst Rev. 2004;2004(3):CD004727. doi: 
      10.1002/14651858.CD004727.pub2.