PMID- 15266553
OWN - NLM
STAT- MEDLINE
DCOM- 20041110
LR  - 20161124
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 53
IP  - 4
DP  - 2004 Sep 15
TI  - MDMA-evoked changes in cerebral blood flow in living porcine brain: correlation 
      with hyperthermia.
PG  - 214-21
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) acutely releases intraneuronal dopamine 
      and serotonin and evokes hyperthermia which is linked to toxicity for serotonin 
      fibers. The acute effects of MDMA on cerebral blood flow (CBF) in living brain 
      have not been described in an animal model of MDMA intoxication. We predicted 
      that MDMA-induced hyperthermia should correlate with increased CBF in the 
      hypothalamus, a serotonin-rich brain region subserving thermoregulation. To test 
      this prediction, we used positron emission tomography with statistical parametric 
      mapping for exploratory analysis of the focal changes in the magnitude of CBF in 
      the anesthetized female Landrace pig (n = 9) at 30 and 150 min after acute 
      challenge with MDMA-HCl (1 mg/kg, i.v.). The MDMA treatment was followed by 
      increased CBF in the occipital cortex and in the medial mesencephalon overlapping 
      the dorsal raphe nucleus, and reduced CBF in the cerebellar vermis and in a 
      cluster in the medulla encompassing the left locus coeruleus. The individual 
      increase of body temperature correlated positively with increased CBF in the 
      vicinity of the raphe nucleus, in the hypothalamus (regions linked to 
      thermoregulation), and also in the medial frontal cortex, which together comprise 
      the regions receiving the most dense serotonin innervations in pig brain. Thus, 
      individual differences in the susceptibility to MDMA-induced hyperthermia in this 
      population correlated with the magnitude of focal increases in CBF within 
      specific brain regions endowed with a dense serotonin innervation, including 
      regions linked to thermoregulation.
FAU - Rosa-Neto, Pedro
AU  - Rosa-Neto P
AD  - Center for Functionally Integrative Neuroscience, Aarhus University and PET 
      Center, Aarhus University Hospitals, Aarhus C, 8000, Denmark. pedro@pet.auh.dk
FAU - Olsen, Aage K
AU  - Olsen AK
FAU - Gjedde, Albert
AU  - Gjedde A
FAU - Watanabe, Hideaki
AU  - Watanabe H
FAU - Cumming, Paul
AU  - Cumming P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Brain/blood supply/diagnostic imaging/*drug effects
MH  - Cerebral Arteries/diagnostic imaging/*drug effects/physiology
MH  - Cerebrovascular Circulation/*drug effects/physiology
MH  - Disease Models, Animal
MH  - Female
MH  - Fever/*chemically induced/physiopathology
MH  - Hypothalamus/blood supply/diagnostic imaging/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Prefrontal Cortex/blood supply/diagnostic imaging/drug effects
MH  - Presynaptic Terminals/drug effects/metabolism
MH  - Raphe Nuclei/blood supply/diagnostic imaging/drug effects
MH  - Serotonin/metabolism
MH  - Sus scrofa/anatomy & histology/*physiology
MH  - Tomography, Emission-Computed
EDAT- 2004/07/22 05:00
MHDA- 2004/11/13 09:00
CRDT- 2004/07/22 05:00
PHST- 2004/07/22 05:00 [pubmed]
PHST- 2004/11/13 09:00 [medline]
PHST- 2004/07/22 05:00 [entrez]
AID - 10.1002/syn.20052 [doi]
PST - ppublish
SO  - Synapse. 2004 Sep 15;53(4):214-21. doi: 10.1002/syn.20052.