PMID- 15266820
OWN - NLM
STAT- MEDLINE
DCOM- 20040824
LR  - 20071115
IS  - 1000-503X (Print)
IS  - 1000-503X (Linking)
VI  - 26
IP  - 3
DP  - 2004 Jun
TI  - [Comparison of unfractionated heparin and low molecular weight heparin in 
      pulmonary thromboembolism: meta-analysis].
PG  - 221-6
AB  - OBJECTIVE: To pool the data of studies about anticoagulation in non-massive 
      pulmonary thromboembolism (PTE) and evaluate the efficacy and safety of low 
      molecular weight heparin (LMWH) and unfractionated heparin (UFH) as the initial 
      treatment. METHODS: MEDLINE CD-ROM from January 1966 to August 2003 and CBM 
      CD-ROM from January 1978 to August 2003 were chosen for searching the randomized 
      clinical trials (RCTs) that compared the efficacy or safety of LMWH and UFH in 
      non-massive PTE. A meta-analysis was employed to evaluate the results of these 
      two therapies. RESULTS: Five RCTs including 999 cases were analyzed. Compared 
      with UFH, the combined odds ratio (OR) of LMWH in treating PTE was as follows: 
      (1) The total OR of mortality of PTE patients treated with LMWH was 0.81 (95%CI 
      0.36-1.81, P > 0.05); (2) The total OR of recurrence of venous thromboembolism 
      (VTE) in PTE patients treated with LMWH was 0.37 (95%CI 0.14-1.00, P=0.05); (3) 
      The total OR of bleeding in LMWH was 0.47 (95%CI 0.16-1.39, P > 0.05);(4) The 
      total OR of heparin-induced thrombocytopenia (HIT) in LMWH was 0.66 (95%CI 
      0.06-6.92, P > 0.05). CONCLUSIONS: LMWH and UFH can reduce the mortality and 
      recurrence of VTE in patients with PTE in the same degree. The risk of major 
      bleeding was similar in the two treatment groups. Initial subcutaneous therapy 
      with the LMWH appeared to be as effective and safe as intravenous UFH in the 
      initial treatment of PTE.
FAU - Zhai, Zhen-guo
AU  - Zhai ZG
AD  - Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital 
      University of Medical Sciences, Beijing 100020, China. zhaizhenguo@163.net
FAU - Wang, Chen
AU  - Wang C
FAU - Liu, Yan-mei
AU  - Liu YM
FAU - Qin, Zhi-qiang
AU  - Qin ZQ
LA  - chi
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao
JT  - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
JID - 8006230
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Anticoagulants/therapeutic use
MH  - Female
MH  - Heparin/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/*therapeutic use
MH  - Humans
MH  - Male
MH  - Odds Ratio
MH  - Pulmonary Embolism/*drug therapy/mortality
MH  - Randomized Controlled Trials as Topic
MH  - Recurrence
MH  - *Thrombolytic Therapy
MH  - Treatment Outcome
EDAT- 2004/07/23 05:00
MHDA- 2004/08/25 05:00
CRDT- 2004/07/23 05:00
PHST- 2004/07/23 05:00 [pubmed]
PHST- 2004/08/25 05:00 [medline]
PHST- 2004/07/23 05:00 [entrez]
PST - ppublish
SO  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Jun;26(3):221-6.