PMID- 15269380
OWN - NLM
STAT- MEDLINE
DCOM- 20040824
LR  - 20200303
IS  - 0022-1317 (Print)
IS  - 0022-1317 (Linking)
VI  - 85
IP  - Pt 8
DP  - 2004 Aug
TI  - Immunization with dendritic cells can break immunological ignorance toward a 
      persisting virus in the central nervous system and induce partial protection 
      against intracerebral viral challenge.
PG  - 2379-2387
LID - 10.1099/vir.0.80115-0 [doi]
AB  - Dendritic cells (DCs) have been used successfully to induce CD8 T cells that 
      control virus infections and growth of tumours. The efficacy of DC-mediated 
      immunization for the control of neurotropic Borna disease virus (BDV) in mice was 
      evaluated. Certain strains of mice only rarely develop spontaneous neurological 
      disease, despite massive BDV replication in the brain. Resistance to disease is 
      due to immunological ignorance toward BDV antigen in the central nervous system. 
      Ignorance in mice can be broken by immunization with DCs coated with TELEISSI, a 
      peptide derived from the N protein of BDV, which represents the immunodominant 
      cytotoxic T lymphocyte epitope in H-2(k) mice. Immunization with TELEISSI-coated 
      DCs further induced solid protective immunity against intravenous challenge with 
      a recombinant vaccinia virus expressing BDV-N. Interestingly, however, this 
      immunization scheme induced only moderate protection against intracerebral 
      challenge with BDV, suggesting that immune memory raised against a shared antigen 
      may be sufficient to control a peripherally replicating virus, but not a highly 
      neurotropic virus that is able to avoid activation of T cells. This difference 
      might be due to the lack of BDV-specific CD4 T cells and/or inefficient 
      reactivation of DC-primed, BDV-specific CD8 T cells by the locally restricted BDV 
      infection. Thus, a successful vaccine against persistent viruses with strong 
      neurotropism should probably induce antiviral CD8 (as well as CD4) T-cell 
      responses and should favour the accumulation of virus-specific memory T cells in 
      cervical lymph nodes.
FAU - Fassnacht, Ulrike
AU  - Fassnacht U
AD  - Department of Virology, University of Freiburg, Hermann-Herder-Str. 11, D-79104 
      Freiburg, Germany.
FAU - Ackermann, Andreas
AU  - Ackermann A
AD  - Department of Virology, University of Freiburg, Hermann-Herder-Str. 11, D-79104 
      Freiburg, Germany.
FAU - Staeheli, Peter
AU  - Staeheli P
AD  - Department of Virology, University of Freiburg, Hermann-Herder-Str. 11, D-79104 
      Freiburg, Germany.
FAU - Hausmann, Jurgen
AU  - Hausmann J
AD  - Department of Virology, University of Freiburg, Hermann-Herder-Str. 11, D-79104 
      Freiburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (Nucleocapsid Proteins)
RN  - 0 (Peptide Fragments)
SB  - IM
MH  - Animals
MH  - Borna disease virus/*immunology
MH  - Brain/*virology
MH  - Dendritic Cells/*immunology
MH  - Immunization
MH  - Immunologic Memory
MH  - Mice
MH  - Nucleocapsid Proteins/immunology
MH  - Peptide Fragments/immunology
EDAT- 2004/07/23 05:00
MHDA- 2004/08/25 05:00
CRDT- 2004/07/23 05:00
PHST- 2004/07/23 05:00 [pubmed]
PHST- 2004/08/25 05:00 [medline]
PHST- 2004/07/23 05:00 [entrez]
AID - 10.1099/vir.0.80115-0 [doi]
PST - ppublish
SO  - J Gen Virol. 2004 Aug;85(Pt 8):2379-2387. doi: 10.1099/vir.0.80115-0.