PMID- 15270812
OWN - NLM
STAT- MEDLINE
DCOM- 20050317
LR  - 20181130
IS  - 0307-7772 (Print)
IS  - 0307-7772 (Linking)
VI  - 29
IP  - 4
DP  - 2004 Aug
TI  - A systematic review of case-control studies of human papillomavirus infection in 
      laryngeal squamous cell carcinoma.
PG  - 301-6
AB  - A role for human papillomavirus (HPV) has been suggested in laryngeal squamous 
      cell carcinoma (LSCC). In order to quantitate the available evidence, we reviewed 
      studies examining the risk of laryngeal cancer-associated HPV. PubMed was 
      searched for case-control studies conducted worldwide and published in any 
      language since 1966. Relevant papers were hand-searched and cross-referenced. Six 
      studies met the inclusion criteria. The studies are heterogeneous in the methods 
      used to harvest tissue samples and techniques for detecting the virus within the 
      tissue. HPV-16 positivity among cases ranged from 2.7% to 46.9% and 0-5.7% among 
      controls. Two studies showed a significantly increased risk of LSCC if HPV-16 was 
      present (OR 18.5, 95% CI 2.2-154.8, OR 2.6, 95% CI 1.1-6.0). An increased risk 
      was also observed for glottic versus supraglottic cancer in one study (OR 9.69, 
      95% CI 1.47-64.04). The direction of effect is towards an increase in risk of 
      LSCC in people with evidence of HPV-16 infection. There is marked heterogeneity 
      in the methods used to detect the virus and frequency with which it is detected. 
      An adequately powered study using a reliable detection technique is required to 
      confirm and quantify this risk and to examine effect modification.
FAU - Rees, L
AU  - Rees L
AD  - Laryngeal Research Group, Department of Otolaryngology, Division of Surgery, 
      University of Bristol, Bristol, UK.
FAU - Birchall, M
AU  - Birchall M
FAU - Bailey, M
AU  - Bailey M
FAU - Thomas, S
AU  - Thomas S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Clin Otolaryngol Allied Sci
JT  - Clinical otolaryngology and allied sciences
JID - 7701793
SB  - IM
MH  - Carcinoma, Squamous Cell/*virology
MH  - Case-Control Studies
MH  - Humans
MH  - Laryngeal Neoplasms/*virology
MH  - Papillomaviridae/*isolation & purification
MH  - Papillomavirus Infections/*complications
MH  - Tumor Virus Infections/*complications
RF  - 22
EDAT- 2004/07/24 05:00
MHDA- 2005/03/18 09:00
CRDT- 2004/07/24 05:00
PHST- 2004/07/24 05:00 [pubmed]
PHST- 2005/03/18 09:00 [medline]
PHST- 2004/07/24 05:00 [entrez]
AID - COA841 [pii]
AID - 10.1111/j.1365-2273.2004.00841.x [doi]
PST - ppublish
SO  - Clin Otolaryngol Allied Sci. 2004 Aug;29(4):301-6. doi: 
      10.1111/j.1365-2273.2004.00841.x.