PMID- 15272285
OWN - NLM
STAT- MEDLINE
DCOM- 20050509
LR  - 20230210
IS  - 0893-3952 (Print)
IS  - 0893-3952 (Linking)
VI  - 18
IP  - 3
DP  - 2005 Mar
TI  - Comparative genomic hybridization analysis of thymic neuroendocrine tumors.
PG  - 358-64
AB  - Thymic neuroendocrine (carcinoid) tumors are a rare neoplasm of the anterior 
      mediastinum. The tumors frequently exhibit a wide spectrum of histology and 
      appear to follow a more aggressive behavior than their nonthymic counterparts. 
      Given the differing clinicopathologic manifestations, thymic neuroendocrine 
      tumors may also possess different cytogenetic abnormalities from those that occur 
      in foregut carcinoid tumors. In this study, we employed comparative genomic 
      hybridization to detect genomic instability in 10 sporadic thymic neuroendocrine 
      tumors and one multiple endocrine neoplasia type 1 (MEN1)-associated case. Gross 
      chromosomal imbalances were found in nine cases, including gains of chromosomal 
      material on regions X, 8, 18 and 20p and losses on 3, 6, 9q, 13q and 11q. We did 
      not observe deletion at locus 11q13 where the MEN1 gene is located. These 
      findings were essentially dissimilar to those reported in sporadic and 
      MEN1-associated foregut carcinoid tumors. Consequently, we consider that a 
      distinctive cytogenetic mechanism is at work in the development of thymic 
      neuroendocrine tumors, which is different from that of foregut carcinoid tumors.
FAU - Pan, Chin-Chen
AU  - Pan CC
AD  - Department of Pathology, National Yang-Ming University, Taipei, Taiwan.
FAU - Jong, Yiin-Jeng
AU  - Jong YJ
FAU - Chen, Yann-Jang
AU  - Chen YJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Neuroendocrine Tumors/*genetics/pathology
MH  - Nucleic Acid Hybridization/*methods
MH  - Survival Analysis
MH  - Thymus Neoplasms/*genetics/pathology
EDAT- 2004/07/24 05:00
MHDA- 2005/05/10 09:00
CRDT- 2004/07/24 05:00
PHST- 2004/07/24 05:00 [pubmed]
PHST- 2005/05/10 09:00 [medline]
PHST- 2004/07/24 05:00 [entrez]
AID - S0893-3952(22)04163-1 [pii]
AID - 10.1038/modpathol.3800246 [doi]
PST - ppublish
SO  - Mod Pathol. 2005 Mar;18(3):358-64. doi: 10.1038/modpathol.3800246.