PMID- 15273434
OWN - NLM
STAT- MEDLINE
DCOM- 20041123
LR  - 20131121
IS  - 1015-9770 (Print)
IS  - 1015-9770 (Linking)
VI  - 18
IP  - 3
DP  - 2004
TI  - Serum cardiac troponin I in acute stroke is related to serum cortisol and 
      TNF-alpha.
PG  - 194-9
AB  - BACKGROUND: Serum cardiac troponin I (cTnI) is a specific marker of myocardial 
      injury related to in-patient fatality and cardiac injury in acute stroke. We 
      investigated whether cTnI in acute stroke is related to serum cortisol, acute 
      inflammatory response, and insular damage. We also investigated whether cTnI 
      predicted outcome at 3 months. PATIENTS AND METHODS: The study was based on 155 
      patients with CT-confirmed acute cerebral infarction and study inclusion within 
      24 h (50% within 12 h) of stroke onset. Blood samples were obtained on inclusion. 
      Stroke severity was assessed by the Scandinavian Stroke Scale (SSS) and outcome 
      was assessed by the modified Rankin Scale (mRS), death or dependency was defined 
      as mRS > or =3 three months after stroke. RESULTS: 35% of all patients and 63% of 
      patients who died within 3 months were troponin positive. Tumor necrosis 
      factor-alpha (TNF-alpha) and cortisol were independently related to detection of 
      cTnI: TNF-alpha(+100 pg/ml) OR 1.5 (CI 95% 1.1-2.2), cortisol(+100 nmol/l) OR 1.1 
      (CI 95% 1.01-1.2). SSS and age were also included in this model and did not reach 
      significance. cTnI positivity was, together with age, stroke severity and 
      prestroke mRS, but not s-cortisol, an independent explanatory variable of outcome 
      at 3 months (death or dependency) with OR 4.1 (CI 95% 1.1-14.5). cTnI did not 
      relate to insular involvement. CONCLUSION: In this study, cortisol and TNF-alpha 
      were independently related to cTnI, which was predictive of 3-month prognosis.
CI  - Copyright 2004 S. Karger AG, Basel
FAU - Christensen, Hanne
AU  - Christensen H
AD  - Department of Neurology, Bispebjerg Hospital, University of Copenhagen, 
      Copenhagen, Denmark. hc04@bbh.hosp.dk
FAU - Johannesen, Helle Hjorth
AU  - Johannesen HH
FAU - Christensen, Anders Fogh
AU  - Christensen AF
FAU - Bendtzen, Klaus
AU  - Bendtzen K
FAU - Boysen, Gudrun
AU  - Boysen G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040722
PL  - Switzerland
TA  - Cerebrovasc Dis
JT  - Cerebrovascular diseases (Basel, Switzerland)
JID - 9100851
RN  - 0 (Troponin I)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Confidence Intervals
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Logistic Models
MH  - Male
MH  - Multivariate Analysis
MH  - Myocardium/*metabolism
MH  - Odds Ratio
MH  - Prognosis
MH  - Stroke/*blood
MH  - Survival Analysis
MH  - Troponin I/*metabolism
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2004/07/27 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/07/27 05:00
PHST- 2003/11/03 00:00 [received]
PHST- 2004/02/14 00:00 [accepted]
PHST- 2004/07/27 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/07/27 05:00 [entrez]
AID - 79941 [pii]
AID - 10.1159/000079941 [doi]
PST - ppublish
SO  - Cerebrovasc Dis. 2004;18(3):194-9. doi: 10.1159/000079941. Epub 2004 Jul 22.