PMID- 15273456
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20181113
IS  - 1383-875X (Print)
IS  - 1383-875X (Linking)
VI  - 11
IP  - 1
DP  - 2004 Aug
TI  - Implantable cardioverter defibrillator therapy in patients with ischemic or 
      non-ischemic cardiomyopathy and nonsustained ventricular tachycardia.
PG  - 59-65
AB  - BACKGROUND: Mortality benefit from implantable cardioverter defibrillator (ICD) 
      therapy in ischemic cardiomyopathy (ICM) with non-sustained ventricular 
      tachycardia (NS-VT) and inducible VT is well defined. Although NS-VT may suggest 
      an increased risk of sudden cardiac death (SCD) in non-ischemic cardiomyopathy 
      (NICM), the role of ICD therapy is unclear. This retrospective study compares 
      follow-up data in these two groups after ICD implantation. METHODS: 153 
      consecutive patients with ICD implantation for NS-VT were analyzed. ICM patients 
      received an ICD if they had inducible VT at electrophysiology study (EPS). NICM 
      patients did not routinely undergo EPS before ICD implantation. RESULTS: There 
      were 48 patients (33 males) in NICM group and 105 patients (89 males) in the ICM 
      group. Baseline characteristics including mean ejection fraction (EF), 
      distribution in various New York Heart Association (NYHA) classes, and the mean 
      duration of follow up in the two groups were similar. 50% of the patients in the 
      NICM group and 36% in the ICM group received appropriate therapies (p = 0.106). 
      The mean number of appropriate therapies in the two groups were similar (23.3 +/- 
      56.7 and 22.5 +/- 59.5 respectively, p = NS). The percentage of patients with 
      inappropriate therapies in the two groups were 27% and 23% respectively (p = NS). 
      Patients in the NICM group received appropriate ICD discharges at a greater rate 
      (p = 0.02). CONCLUSION: Patients undergoing ICD implantation for NICM and NS-VT 
      receive appropriate ICD therapy at a greater rate than those implanted for ICM, 
      NS-VT, and a positive EPS. Although these data do not prove survival benefit in 
      NICM, they suggest a beneficial effect.
FAU - Evonich, Rudolph F
AU  - Evonich RF
AD  - Thoracic and Cardiovascular Institute, Department of Epidemiology, Michigan State 
      University, Lansing, Michigan 48912, USA.
FAU - Maheshwari, Alok
AU  - Maheshwari A
FAU - Gardiner, Joseph C
AU  - Gardiner JC
FAU - Khasnis, Atul
AU  - Khasnis A
FAU - Kantipudi, Sricharan
AU  - Kantipudi S
FAU - Ip, John H
AU  - Ip JH
FAU - Grimes, Denise
AU  - Grimes D
FAU - Hayter, Gregory
AU  - Hayter G
FAU - Thakur, Ranjan K
AU  - Thakur RK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - J Interv Card Electrophysiol
JT  - Journal of interventional cardiac electrophysiology : an international journal of 
      arrhythmias and pacing
JID - 9708966
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiomyopathies/physiopathology/*therapy
MH  - *Defibrillators, Implantable
MH  - Electrophysiologic Techniques, Cardiac
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Michigan
MH  - Middle Aged
MH  - Myocardial Ischemia/physiopathology/*therapy
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - Survival Analysis
MH  - Tachycardia, Ventricular/physiopathology/*therapy
MH  - Treatment Outcome
EDAT- 2004/07/27 05:00
MHDA- 2006/08/19 09:00
CRDT- 2004/07/27 05:00
PHST- 2004/07/27 05:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2004/07/27 05:00 [entrez]
AID - 5276804 [pii]
AID - 10.1023/B:JICE.0000035931.10063.50 [doi]
PST - ppublish
SO  - J Interv Card Electrophysiol. 2004 Aug;11(1):59-65. doi: 
      10.1023/B:JICE.0000035931.10063.50.