PMID- 15276851
OWN - NLM
STAT- MEDLINE
DCOM- 20050201
LR  - 20071115
IS  - 0021-9975 (Print)
IS  - 0021-9975 (Linking)
VI  - 131
IP  - 2-3
DP  - 2004 Aug-Oct
TI  - Expression of monocyte chemoattractant protein-1 and macrophage inflammatory 
      protein-1 in porcine circovirus 2-induced granulomatous inflammation.
PG  - 121-6
AB  - The expression of monocyte chemoattractant protein-1 (MCP-1) and macrophage 
      inflammatory protein-1 (MIP-1) in granulomatous inflammation of lymph nodes was 
      determined in 1-day-old piglets inoculated intranasally with porcine circovirus 2 
      (PCV2). The methods used were reverse transcription-polymerase chain reaction 
      (RT-PCR), granulomatous lesion scoring, and in-situ hybridization. Maximum MCP-1 
      expression and MIP-1 expression were observed at 17 and 21 days post-inoculation 
      (dpi), respectively. Granulomatous lesions of maximum severity were observed 
      somewhat later (28 dpi). A close cell to cell relation between PCV2 and the two 
      cytokines in serial sections from lymph nodes suggested that their induction was 
      a direct response to PCV2. The results provide evidence of the ability of MCP-1 
      and MIP-1 to induce granulomatous inflammation in vivo.
FAU - Kim, J
AU  - Kim J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine and School of 
      Agricultural Biotechnology, Seoul National University, San 56-1, Shillim-Dong, 
      Kwanak-Gu 141-742, Seoul, South Korea.
FAU - Chae, C
AU  - Chae C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Macrophage Inflammatory Proteins)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/*biosynthesis
MH  - Chemokine CCL4
MH  - Circoviridae Infections/immunology/*pathology
MH  - Circovirus/immunology
MH  - Granuloma/immunology/metabolism/*pathology
MH  - In Situ Hybridization
MH  - Inflammation/immunology/metabolism/*pathology
MH  - Lymph Nodes/immunology/metabolism
MH  - Macrophage Inflammatory Proteins/*biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Swine
EDAT- 2004/07/28 05:00
MHDA- 2005/02/03 09:00
CRDT- 2004/07/28 05:00
PHST- 2003/09/22 00:00 [received]
PHST- 2004/02/05 00:00 [accepted]
PHST- 2004/07/28 05:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/07/28 05:00 [entrez]
AID - S0021997504000258 [pii]
AID - 10.1016/j.jcpa.2004.02.001 [doi]
PST - ppublish
SO  - J Comp Pathol. 2004 Aug-Oct;131(2-3):121-6. doi: 10.1016/j.jcpa.2004.02.001.