PMID- 15277695
OWN - NLM
STAT- MEDLINE
DCOM- 20050307
LR  - 20220408
IS  - 1066-5099 (Print)
IS  - 1066-5099 (Linking)
VI  - 22
IP  - 4
DP  - 2004
TI  - Plasticity of bone marrow-derived stem cells.
PG  - 487-500
AB  - Stem cell plasticity refers to the ability of adult stem cells to acquire mature 
      phenotypes that are different from their tissue of origin. Adult bone marrow 
      cells (BMCs) include two populations of bone marrow stem cells (BMCs): 
      hematopoietic stem cells (HSCs), which give rise to all mature lineages of blood, 
      and mesenchymal stem cells (MSCs), which can differentiate into bone, cartilage, 
      and fat. In this article, we review the literature that lends credibility to the 
      theory that highly plastic BMCs have a role in maintenance and repair of 
      nonhematopoietic tissue. We discuss the possible mechanisms by which this may 
      occur. Also reviewed is the possibility that adult BMCs can change their gene 
      expression profile after fusion with a mature cell, which has brought into 
      question whether this stem cell plasticity is real.
FAU - Grove, Joanna E
AU  - Grove JE
AD  - Department of Laboratory Medicine, Yale University School of Medicine, P.O. Box 
      8035, 333 Cedar Street, New Haven, CT 06520-8035, USA. joanna.grove@yale.edu
FAU - Bruscia, Emanuela
AU  - Bruscia E
FAU - Krause, Diane S
AU  - Krause DS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/*cytology
MH  - Cell Differentiation/*physiology
MH  - Hematopoietic Stem Cells/*cytology
MH  - Humans
MH  - Stem Cell Transplantation
MH  - Stem Cells/*cytology
MH  - Transplantation, Heterologous
RF  - 110
EDAT- 2004/07/28 05:00
MHDA- 2005/03/08 09:00
CRDT- 2004/07/28 05:00
PHST- 2004/07/28 05:00 [pubmed]
PHST- 2005/03/08 09:00 [medline]
PHST- 2004/07/28 05:00 [entrez]
AID - 22/4/487 [pii]
AID - 10.1634/stemcells.22-4-487 [doi]
PST - ppublish
SO  - Stem Cells. 2004;22(4):487-500. doi: 10.1634/stemcells.22-4-487.