PMID- 15277696
OWN - NLM
STAT- MEDLINE
DCOM- 20050307
LR  - 20071115
IS  - 1066-5099 (Print)
IS  - 1066-5099 (Linking)
VI  - 22
IP  - 4
DP  - 2004
TI  - Cellular immunotherapy with dendritic cells in cancer: current status.
PG  - 501-13
AB  - Dendritic cells (DCs) are specialized antigen-presenting cells whose 
      immunogenicity leads to the induction of antigen-specific immune responses. DCs 
      can easily be generated ex vivo from peripheral blood monocytes or bone 
      marrow/circulating hematopoietic stem cells cultured in the presence of cytokine 
      cocktails. DCs have been used in numerous clinical trials to induce antitumor 
      immune responses in cancer patients. The studies carried out to date have 
      demonstrated that DCs pulsed with tumor antigens can be safely administered, and 
      this approach produces antigen-specific immune responses. Clinical responses have 
      been observed in a minority of patients. It is likely that either heavy medical 
      pretreatment or the presence of large tumor burdens (or both) is among the causes 
      that impair the benefits of vaccination. Hence, the use of DCs should be 
      considered in earlier stages of disease such as the adjuvant setting. Prospective 
      applications of DCs extend to their use in allogeneic adoptive immunotherapy to 
      specifically target the graft versus tumor reaction. DCs continue to hold promise 
      for cellular immunotherapy, and further investigation is required to determine 
      the clinical settings in which patients will most benefit from the use of this 
      cellular immune adjuvant.
FAU - Nencioni, Alessio
AU  - Nencioni A
AD  - Massachusetts Institute of Technology, Center for Cancer Research, Cambridge, 
      USA.
FAU - Brossart, Peter
AU  - Brossart P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Cancer Vaccines/therapeutic use
MH  - Clinical Trials as Topic
MH  - Dendritic Cells/*transplantation
MH  - Humans
MH  - Immunotherapy/*methods
MH  - Immunotherapy, Adoptive/*methods
MH  - Neoplasms/*immunology/*therapy
MH  - Transplantation, Homologous
RF  - 107
EDAT- 2004/07/28 05:00
MHDA- 2005/03/08 09:00
CRDT- 2004/07/28 05:00
PHST- 2004/07/28 05:00 [pubmed]
PHST- 2005/03/08 09:00 [medline]
PHST- 2004/07/28 05:00 [entrez]
AID - 22/4/501 [pii]
AID - 10.1634/stemcells.22-4-501 [doi]
PST - ppublish
SO  - Stem Cells. 2004;22(4):501-13. doi: 10.1634/stemcells.22-4-501.