PMID- 15277733
OWN - NLM
STAT- MEDLINE
DCOM- 20050412
LR  - 20190819
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 68
IP  - 8
DP  - 2004 Aug
TI  - Ongoing myocardial damage in chronic heart failure is related to activated tumor 
      necrosis factor and Fas/Fas ligand system.
PG  - 747-50
AB  - BACKGROUND: Elevated concentrations of cardiac troponin T and heart-type fatty 
      acid-binding protein (H-FABP) identify patients with chronic heart failure (CHF) 
      and ongoing myocardial damage (OMD) who are at increased risk for future cardiac 
      events. Cardiomyocyte necrosis and/or apoptosis via activated tumor necrosis 
      factor (TNF) and the Fas/Fas ligand (FasL) system may be related to the 
      development of OMD. METHODS AND RESULTS: The serum concentrations of H-FABP, a 
      sensitive marker of membrane damage of cardiomyocytes, soluble Fas (sFas) and 
      TNF-alpha were measured in 38 patients with CHF. The concentrations of H-FABP, 
      TNF-alpha and s-Fas in patients with New York Heart Association (NYHA) III + IV 
      were all significantly higher than in those patients in NYHA II (H-FABP; III + IV 
      9.3+/-5.9 vs II 5.1+/-1.8 ng/ml, p=0.003, TNF-alpha; III + IV 10.5+/-3.8 vs II 
      8.0+/-2.7 pg/ml, p=0.02, sFas; III + IV 3.36+/-1.37 vs II 2.58 +/-0.84 ng/ml, 
      p=0.03). Increased concentrations of H-FABP significantly correlated with the 
      concentrations of TNF- alpha (r=0.57, p=0.0001) and sFas (r=0.69, p<0.0001), 
      independent of renal function. CONCLUSION: OMD detected by H-FABP, a marker of 
      membrane damage, is related to activated TNF and the Fas/FasL system, which 
      suggests a pathophysiological role of cardiomyocyte necrosis and/or apoptosis in 
      patients with worsening heart failure.
FAU - Setsuta, Koichi
AU  - Setsuta K
AD  - Division of Cardiology, Department of Medicine, Tokyo Metropolitan Komagome 
      Hospital, Japan.
FAU - Seino, Yoshihiko
AU  - Seino Y
FAU - Ogawa, Takeshi
AU  - Ogawa T
FAU - Ohtsuka, Toshiaki
AU  - Ohtsuka T
FAU - Seimiya, Kohji
AU  - Seimiya K
FAU - Takano, Teruo
AU  - Takano T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Biomarkers)
RN  - 0 (Carrier Proteins)
RN  - 0 (FASLG protein, human)
RN  - 0 (Fas Ligand Protein)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (fas Receptor)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Carrier Proteins/blood
MH  - Fas Ligand Protein
MH  - Fatty Acid-Binding Proteins
MH  - Female
MH  - Heart Failure/immunology/*pathology
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*blood
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Regression Analysis
MH  - Tumor Necrosis Factor-alpha/*analysis
MH  - fas Receptor/*blood
EDAT- 2004/07/28 05:00
MHDA- 2005/04/13 09:00
CRDT- 2004/07/28 05:00
PHST- 2004/07/28 05:00 [pubmed]
PHST- 2005/04/13 09:00 [medline]
PHST- 2004/07/28 05:00 [entrez]
AID - 10.1253/circj.68.747 [doi]
PST - ppublish
SO  - Circ J. 2004 Aug;68(8):747-50. doi: 10.1253/circj.68.747.