PMID- 15279200
OWN - NLM
STAT- MEDLINE
DCOM- 20040816
LR  - 20070222
IS  - 0006-8969 (Print)
IS  - 0006-8969 (Linking)
VI  - 56
IP  - 5
DP  - 2004 May
TI  - [High-dose intravenous immunoglobulin in the treatment of sensory ataxic 
      neuropathy with Sjogren's syndrome: a case report].
PG  - 421-4
AB  - We report herein a case of sensory ataxic neuropathy with Sjogren's syndrome 
      (SS-SAN) who became dramatically improved in response to high-dose intravenous 
      immunoglobulin treatment (IVIg). An 81-year-old man began to feel numbness in his 
      hands and feet in August 2002. Because he became unsteady and could not do 
      skillfull movement, he was admitted to our hospital in May 2003. On neurological 
      examination, all tendon reflexes were absent. His vibratory and position senses 
      were severely impaired to knees and elbows. Touch, temperature, and pinprick 
      sensations were mildly disturbed in a glove-stocking distribution. Coordination 
      was clumsy in all limbs because of sensory loss. He had gait ataxia with Romberg 
      sign. Nerve conduction study revealed that sensory nerve action potentials were 
      absent. He was diagnosed as having SS-SAN because Schirmer test, Saxon test and 
      both SS-A and SS-B antibodies were positive. Thereafter, Mg, 400 mg/kg daily for 
      5 days, was administered. His sensory impairment began to improve 2 days after 
      Mg. Subsequently, he could walk steadily without ataxia. It is considered that 
      IVIg may be an effective treatment for SS-SAN.
FAU - Taguchi, Yoshiharu
AU  - Taguchi Y
AD  - The Second Department of Internal Medicine, Toyama Medical & Pharmaceutical 
      University, 2630 Sugitani, Toyama 930-0194, Japan.
FAU - Takashima, Shutaro
AU  - Takashima S
FAU - Takata, Maiko
AU  - Takata M
FAU - Dougu, Nobuhiro
AU  - Dougu N
FAU - Asaoka, Etsuko
AU  - Asaoka E
FAU - Inoue, Hiroshi
AU  - Inoue H
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - No To Shinkei
JT  - No to shinkei = Brain and nerve
JID - 0413550
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Ataxia/*therapy
MH  - Humans
MH  - Immunoglobulins, Intravenous/*administration & dosage
MH  - Male
MH  - Nervous System Diseases/*therapy
MH  - Sensation Disorders/*therapy
MH  - Sjogren's Syndrome/*complications
EDAT- 2004/07/29 05:00
MHDA- 2004/08/18 05:00
CRDT- 2004/07/29 05:00
PHST- 2004/07/29 05:00 [pubmed]
PHST- 2004/08/18 05:00 [medline]
PHST- 2004/07/29 05:00 [entrez]
PST - ppublish
SO  - No To Shinkei. 2004 May;56(5):421-4.