PMID- 15279637
OWN - NLM
STAT- MEDLINE
DCOM- 20050125
LR  - 20220408
IS  - 0309-0167 (Print)
IS  - 0309-0167 (Linking)
VI  - 45
IP  - 2
DP  - 2004 Aug
TI  - Survivin expression is a negative prognostic marker in laryngeal squamous cell 
      carcinoma and is associated with p53 accumulation.
PG  - 180-6
AB  - AIMS: To investigate survivin expression in laryngeal squamous cell carcinoma 
      (LSCC), its prognostic significance and relation to p53 status. Survivin is an 
      inhibitor of apoptosis protein that is overexpressed in cancer. It has been 
      implicated in both prevention of apoptosis and cell cycle regulation. It has been 
      suggested that wild-type p53 represses survivin expression. METHODS AND RESULTS: 
      Expression of survivin and p53 was analysed in 68 archival biopsy specimens of 
      LSCC by immunohistochemistry. Survivin was detected in 67 of 68 LSCC cases; the 
      proportion of survivin-positive cells varied from 8.2% to 100%. It was localized 
      in the nucleus and/or cytoplasm of tumour cells. Of LSCC cases, 31.8% were p53+. 
      The number of survivin-positive cells was significantly higher in the p53+ group. 
      A high level of survivin expression and a supraglottic site of the tumour were 
      two independent adverse prognostic factors in LSCC. CONCLUSIONS: Survivin is 
      expressed in a varying proportion of cells in virtually all cases of LSCC. A high 
      level of its expression predicts poor survival. Loss of wild-type p53 is a 
      possible mechanism of survivin up-regulation in LSCC.
FAU - Pizem, J
AU  - Pizem J
AD  - Institute of Pathology, Medical Faculty, Ljubljana, Slovenia.
FAU - Cor, A
AU  - Cor A
FAU - Gale, N
AU  - Gale N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Survivin)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Antigens, Neoplasm/*metabolism
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Inhibitor of Apoptosis Proteins
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Male
MH  - Microtubule-Associated Proteins/*metabolism
MH  - Middle Aged
MH  - Neoplasm Proteins
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Survival Rate
MH  - Survivin
MH  - Tumor Suppressor Protein p53/*metabolism
EDAT- 2004/07/29 05:00
MHDA- 2005/01/26 09:00
CRDT- 2004/07/29 05:00
PHST- 2004/07/29 05:00 [pubmed]
PHST- 2005/01/26 09:00 [medline]
PHST- 2004/07/29 05:00 [entrez]
AID - HIS1925 [pii]
AID - 10.1111/j.1365-2559.2004.01925.x [doi]
PST - ppublish
SO  - Histopathology. 2004 Aug;45(2):180-6. doi: 10.1111/j.1365-2559.2004.01925.x.