PMID- 15280152
OWN - NLM
STAT- MEDLINE
DCOM- 20041216
LR  - 20220408
IS  - 0193-1849 (Print)
IS  - 0193-1849 (Linking)
VI  - 287
IP  - 6
DP  - 2004 Dec
TI  - Difference in skeletal muscle function in males vs. females: role of estrogen 
      receptor-beta.
PG  - E1125-31
AB  - Male skeletal muscles are generally faster and have higher maximum power output 
      than female muscles. Conversely, during repeated contractions, female muscles are 
      generally more fatigue resistant and recover faster. We studied the role of 
      estrogen receptor-beta (ERbeta) in this gender difference by comparing 
      contractile function of soleus (mainly slow-twitch) and extensor digitorum longus 
      (fast-twitch) muscles isolated from ERbeta-deficient (ERbeta(-/-)) and wild-type 
      mice of both sexes. Results showed generally shorter contraction and relaxation 
      times in male compared with female muscles, and ERbeta deficiency had no effect 
      on this. Fatigue (induced by repeated tetanic contractions) and recovery of 
      female muscles were not affected by ERbeta deficiency. However, male ERbeta(-/-) 
      muscles were slightly more fatigue resistant and produced higher forces during 
      the recovery period than wild-type male muscles. In fact, female muscles and male 
      ERbeta(-/-) muscles displayed markedly better recovery than male wild-type 
      muscles. Gene screening of male soleus muscles showed 25 genes that were 
      differently expressed in ERbeta(-/-) and wild-type mice. Five of these genes were 
      selected for further analysis: muscle ankyrin repeat protein-2, muscle LIM 
      protein, calsequestrin, parvalbumin, and aquaporin-1. Expression of these genes 
      showed a similar general pattern: increased expression in male and decreased 
      expression in female ERbeta(-/-) muscles. In conclusion, ERbeta deficiency 
      results in increased performance during fatigue and recovery of male muscles, 
      whereas female muscles are not affected. Improved contractile performance of male 
      ERbeta(-/-) mouse muscles was associated with increased expression of mRNAs 
      encoding important muscle proteins.
FAU - Glenmark, Birgitta
AU  - Glenmark B
AD  - Department of Hand Surgery, Stockholm Soder Hospital, SE-118 83 Stockholm, 
      Sweden.
FAU - Nilsson, Maria
AU  - Nilsson M
FAU - Gao, Hui
AU  - Gao H
FAU - Gustafsson, Jan-Ake
AU  - Gustafsson JA
FAU - Dahlman-Wright, Karin
AU  - Dahlman-Wright K
FAU - Westerblad, Hakan
AU  - Westerblad H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040727
PL  - United States
TA  - Am J Physiol Endocrinol Metab
JT  - American journal of physiology. Endocrinology and metabolism
JID - 100901226
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Estrogen Receptor beta/*physiology
MH  - Female
MH  - Gene Expression
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Muscle Contraction/*physiology
MH  - Muscle Fatigue/physiology
MH  - Muscle, Skeletal/metabolism/*physiology
MH  - Oligonucleotide Array Sequence Analysis
MH  - RNA, Messenger/metabolism
MH  - *Sex Characteristics
EDAT- 2004/07/29 05:00
MHDA- 2004/12/17 09:00
CRDT- 2004/07/29 05:00
PHST- 2004/07/29 05:00 [pubmed]
PHST- 2004/12/17 09:00 [medline]
PHST- 2004/07/29 05:00 [entrez]
AID - 00098.2004 [pii]
AID - 10.1152/ajpendo.00098.2004 [doi]
PST - ppublish
SO  - Am J Physiol Endocrinol Metab. 2004 Dec;287(6):E1125-31. doi: 
      10.1152/ajpendo.00098.2004. Epub 2004 Jul 27.