PMID- 15280196
OWN - NLM
STAT- MEDLINE
DCOM- 20041223
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 104
IP  - 10
DP  - 2004 Nov 15
TI  - Long-term acquisition of allergen-specific IgE and asthma following allogeneic 
      bone marrow transplantation from allergic donors.
PG  - 3086-90
AB  - Adoptive transfer of allergen-specific immunoglobulin E (IgE) from atopic donors 
      to nonatopic recipients occurs during the first year following bone marrow 
      transplantation (BMT). Mature B- and T-cell clones with allergen-specific memory 
      and hematopoietic progenitor cells are transferred through BMT. The objective of 
      this study was to characterize the long-term rate of allergic sensitization and 
      development of clinical allergic diseases following BMT from atopic donors. A 
      long-term follow-up study was conducted in a cohort of donor and recipient pairs 
      with moderate-to-severe allergic disease in the donor prior to BMT. Assessments 
      of allergen-specific IgE, clinical rhinitis, and asthma were made in the donors 
      prior to BMT and in the recipients with a mean follow-up of 15.5 years after BMT. 
      From an initial cohort of 12 bone marrow transplant recipients who received 
      marrow from allergic donors, 5 long-term survivors were identified. 
      Allergen-specific IgE transferred from donor to recipient following BMT 
      frequently persisted, and a high rate of de novo allergic sensitization was 
      observed between 1 and 14 years after BMT. These events were associated with 
      elevation in total IgE, and development of allergic rhinitis and asthma at 
      long-term follow-up. We conclude that marrow-derived immune cells from allergic 
      donors can transfer the predisposition to allergy and asthma.
FAU - Hallstrand, Teal S
AU  - Hallstrand TS
AD  - Department of Medicine, University of Washington, BB-1333 Health Sciences, Box 
      356523, 1959 NE Pacific St, Seattle, WA 98195-6523, USA.
FAU - Sprenger, Jay D
AU  - Sprenger JD
FAU - Agosti, Jan M
AU  - Agosti JM
FAU - Longton, Gary M
AU  - Longton GM
FAU - Witherspoon, Robert P
AU  - Witherspoon RP
FAU - Henderson, William R Jr
AU  - Henderson WR Jr
LA  - eng
GR  - HL36444/HL/NHLBI NIH HHS/United States
GR  - HL04231/HL/NHLBI NIH HHS/United States
GR  - K23 HL004231-03/HL/NHLBI NIH HHS/United States
GR  - CA15704/CA/NCI NIH HHS/United States
GR  - K23 HL004231/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20040727
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asthma/*etiology/immunology
MH  - Bone Marrow Transplantation/*adverse effects/*immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/*immunology
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy
MH  - Male
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy
MH  - Pyroglyphidae/immunology
MH  - Rhinitis/immunology
MH  - Tissue Donors
MH  - Transplantation, Homologous
EDAT- 2004/07/29 05:00
MHDA- 2004/12/24 09:00
CRDT- 2004/07/29 05:00
PHST- 2004/07/29 05:00 [pubmed]
PHST- 2004/12/24 09:00 [medline]
PHST- 2004/07/29 05:00 [entrez]
AID - S0006-4971(20)55863-1 [pii]
AID - 10.1182/blood-2004-05-1775 [doi]
PST - ppublish
SO  - Blood. 2004 Nov 15;104(10):3086-90. doi: 10.1182/blood-2004-05-1775. Epub 2004 
      Jul 27.