PMID- 15280623
OWN - NLM
STAT- MEDLINE
DCOM- 20041116
LR  - 20081121
IS  - 0957-5243 (Print)
IS  - 0957-5243 (Linking)
VI  - 15
IP  - 7
DP  - 2004 Sep
TI  - Increased risk of developing hepatocellular carcinoma associated with carriage of 
      the TNF2 allele of the -308 tumor necrosis factor-alpha promoter gene.
PG  - 657-63
AB  - BACKGROUND AND AIMS: Tumor necrosis factor-alpha (TNF-alpha) is a cytokine that 
      may act as an endogenous tumor promoter. A genetic polymorphism of TNF-alpha at 
      position -308 of the promoter region, which includes TNF1 (-308G) and TNF2 
      (-308A) alleles, has been found to be associated with susceptibility to various 
      types of cancer. We conducted a study to evaluate the association between this 
      polymorphism and hepatocellular carcinoma (HCC). METHODS: We recruited 74 HCC 
      patients and 289 healthy controls, and determined their -308 TNF-alpha promoter 
      genotypes through polymerase chain reaction followed by electrophoresis. RESULTS: 
      Carriage of the TNF2 allele was associated with an increased risk of HCC (odds 
      ratio [OR] = 3.5; 95% confidence interval [CI]:[2.1, 6.0]), and a trend toward a 
      significant increase in the risk of developing HCC was observed from TNF1/TNF1, 
      TNF1/TNF2, to TNF2/TNF2 genotypes (p < 0.01). After adjustment for gender, age, 
      and markers of hepatitis B and C, the OR of developing HCC associated with TNF2 
      allele carriage was 5.3 (95% CI: [2.3, 12.1]; p < 0.01) CONCLUSIONS: Carriage of 
      the TNF2 allele is a significant predictor of HCC independent of hepatitis B and 
      C, and therefore it may be used as a biomarker for susceptibility to HCC.
FAU - Ho, Sheng-Yow
AU  - Ho SY
AD  - Department of Radiation Oncology, Sin-Lau Christian Hospital, Tainan, Taiwan.
FAU - Wang, Ying-Jan
AU  - Wang YJ
FAU - Chen, Hen-Li
AU  - Chen HL
FAU - Chen, Chih-Hung
AU  - Chen CH
FAU - Chang, Chih-Jen
AU  - Chang CJ
FAU - Wang, Po-Jen
AU  - Wang PJ
FAU - Chen, Helen H W
AU  - Chen HH
FAU - Guo, How-Ran
AU  - Guo HR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Cancer Causes Control
JT  - Cancer causes & control : CCC
JID - 9100846
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Hepatocellular/*etiology/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Hepatitis B/complications
MH  - Hepatitis C/complications
MH  - Humans
MH  - Liver Neoplasms/*etiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic/genetics
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2004/07/29 05:00
MHDA- 2004/11/17 09:00
CRDT- 2004/07/29 05:00
PHST- 2004/07/29 05:00 [pubmed]
PHST- 2004/11/17 09:00 [medline]
PHST- 2004/07/29 05:00 [entrez]
AID - 5274922 [pii]
AID - 10.1023/B:CACO.0000036173.99930.75 [doi]
PST - ppublish
SO  - Cancer Causes Control. 2004 Sep;15(7):657-63. doi: 
      10.1023/B:CACO.0000036173.99930.75.