PMID- 15281011
OWN - NLM
STAT- MEDLINE
DCOM- 20040913
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 53
IP  - 8
DP  - 2004 Aug
TI  - Homocysteine and disability in hospitalized geriatric patients.
PG  - 1016-20
AB  - Elevated total homocysteine (tHcy) concentrations have been found to be 
      associated with cardiovascular disease and dementia in old age. The present study 
      was performed to identify the prevalence of hyperhomocysteinemia (HHcy) and to 
      analyze the association between tHcy concentration and sociodemographic 
      characteristics, nutritional parameters, and cognitive and functional status in 
      this sample of hospitalized geriatric patients. A total of 214 patients (77% 
      females) 65+ years old admitted into an acute care geriatric ward of an internal 
      medical department in the Northern Italy were studied. tHcy concentration was 
      measured using a high-performance liquid chromatography with fluorescence 
      detection (HPLC-F). Information about nutrition (body mass index [BMI], serum 
      albumin, cholesterol, and transferrin) was collected on admission. Functional 
      status was investigated with the Basic Activities of Daily Living scale (ADL) and 
      the Instrumental Activities of Daily Living scale (IADL); cognitive and affective 
      status were assessed by the Mini-Mental State Evaluation (MMSE) and the Geriatric 
      Depression Scale (GDS). The mean tHcy concentration was 18.4 +/- 13.1 micromol/L; 
      74.2% of males and 68.9% of females had HHcy (> 12 micromol/L). Sixty-four 
      percent of patients with normal serum vitamin B12 and folate concentrations had 
      HHcy. Elevated tHcy concentrations were associated with older age, male gender, 
      increasing serum creatinine, lower MMSE score, and disability. The mean tHcy 
      concentration depended on the occurrence of different diseases. Patients affected 
      by atherosclerotic diseases, such as ischemic heart diseases, cerebrovascular 
      diseases, and dementia had higher mean tHcy concentration than those without 
      diagnosed vascular diseases. In multivariate analysis, vitamin B12, folate, serum 
      albumin, creatinine, and disability emerged as factors associated with tHcy, 
      adjusted for age, gender, education, MMSE score, and atherosclerotic diseases. 
      Our results suggest that the prevalence of HHcy in hospitalized patients is very 
      high, even in subjects with normal cobalamin and folate concentrations. High Hcy 
      concentration can be associated with functional impairment.
CI  - Copyright 2004 Elsevier Inc.
FAU - Marengoni, Alessandra
AU  - Marengoni A
AD  - Division of Internal Medicine I, Spedali Civili, Brescia-Richiedel Foundation, 
      Gussago, Italy.
FAU - Cossi, Stefania
AU  - Cossi S
FAU - De Martinis, Monica
AU  - De Martinis M
FAU - Calabrese, Paolo A
AU  - Calabrese PA
FAU - Orini, Stefania
AU  - Orini S
FAU - Grassi, Vittorio
AU  - Grassi V
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Activities of Daily Living
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Mass Index
MH  - Cognition/physiology
MH  - Comorbidity
MH  - Depression/complications/psychology
MH  - *Disability Evaluation
MH  - Female
MH  - Homocysteine/*blood
MH  - Hospitalization
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Neuropsychological Tests
MH  - Nutritional Status
MH  - Psychiatric Status Rating Scales
MH  - Sex Factors
MH  - Socioeconomic Factors
EDAT- 2004/07/29 05:00
MHDA- 2004/09/14 05:00
CRDT- 2004/07/29 05:00
PHST- 2004/07/29 05:00 [pubmed]
PHST- 2004/09/14 05:00 [medline]
PHST- 2004/07/29 05:00 [entrez]
AID - S0026049504001659 [pii]
AID - 10.1016/j.metabol.2004.03.008 [doi]
PST - ppublish
SO  - Metabolism. 2004 Aug;53(8):1016-20. doi: 10.1016/j.metabol.2004.03.008.