PMID- 15281352
OWN - NLM
STAT- MEDLINE
DCOM- 20040819
LR  - 20191108
IS  - 0301-3073 (Print)
IS  - 0301-3073 (Linking)
VI  - 32
DP  - 2004
TI  - Recent advances in MEN1 gene study for pituitary tumor pathogenesis.
PG  - 265-91
AB  - Evidence of multiple endocrine neoplasia type 1 (MEN1) is found in approximately 
      2.7% of patients with pituitary adenomas. The multicentricity of pituitary 
      adenomas has not yet been proved. Prolactinomas are most frequent in MEN1 
      pituitary tumors. Pituitary tumors with MEN1 are larger in size and more 
      aggressive than without MEN1. Heterozygous germline mutations of MEN1 gene are 
      responsible for MEN1 disorders. Various types of mutations likely causing loss of 
      the gene function have been identified throughout the entire region in patients 
      with MEN1 and related disorders. However, the function of menin, the product of 
      MEN1 gene, remains to be established. Neither mutation hot spot nor 
      phenotype-genotype correlation has been established in classical MEN1. A number 
      of recent studies suggest that somatic mutations in the MEN1 gene do not play 
      prominent role in the pathogenesis of sporadic forms of pituitary adenoma.
FAU - Kameya, Toru
AU  - Kameya T
AD  - Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, 
      Sunta-gun, Shizuoka, Japan. t.kameya@scchr.jp
FAU - Tsukada, Toshihiko
AU  - Tsukada T
FAU - Yamaguchi, Ken
AU  - Yamaguchi K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Front Horm Res
JT  - Frontiers of hormone research
JID - 0320246
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Germ-Line Mutation
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Pituitary Neoplasms/*genetics/pathology
MH  - Prolactinoma/genetics/pathology
MH  - Proto-Oncogene Proteins/*genetics
RF  - 153
EDAT- 2004/07/30 05:00
MHDA- 2004/08/20 05:00
CRDT- 2004/07/30 05:00
PHST- 2004/07/30 05:00 [pubmed]
PHST- 2004/08/20 05:00 [medline]
PHST- 2004/07/30 05:00 [entrez]
AID - 10.1159/000079050 [doi]
PST - ppublish
SO  - Front Horm Res. 2004;32:265-91. doi: 10.1159/000079050.