PMID- 15282170
OWN - NLM
STAT- MEDLINE
DCOM- 20041207
LR  - 20161126
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1658
IP  - 1-2
DP  - 2004 Jul 23
TI  - Thermodynamic and choreographic constraints for energy transduction by cytochrome 
      c oxidase.
PG  - 23-30
AB  - Cooperative effects are fundamental for electroprotonic energy transduction 
      processes, crucial to sustain much of life chemistry. However, the primary 
      cooperative mechanism by which transmembrane proteins couple the downhill 
      transfer of electrons to the uphill activation (acidification) of protic groups 
      is still a matter of great controversy. To understand cooperative processes 
      fully, it is necessary to obtain the microscopic thermodynamic parameters of the 
      functional centres and relate them to the relevant structural features, a task 
      difficult to achieve for large proteins. The approach discussed here explores how 
      this may be done by extrapolation from mechanisms used by simpler proteins 
      operative in similar processes. The detailed study of small, soluble cytochromes 
      performing electroprotonic activation has shown how they use anti-electrostatic 
      effects to control the synchronous movement of charges. These include negative 
      e(-)/H(+) (redox-Bohr effect) cooperativities. This capacity is the basis to 
      discuss an unorthodox mechanism consistent with the available experimental data 
      on the process of electroprotonic energy transduction performed by cytochrome c 
      oxidase (CcO).
FAU - Xavier, Antonio V
AU  - Xavier AV
AD  - Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Rua da 
      Quinta Grande, 6 Apt. 127, 2780-156 Oeiras, Portugal. xavier@itqb.unl.pt
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Cytochromes)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Cytochromes/metabolism
MH  - Electron Transport Complex IV/*chemistry/metabolism
MH  - Energy Transfer
MH  - Enzyme Activation
MH  - Models, Chemical
MH  - Oxidation-Reduction
MH  - Thermodynamics
RF  - 77
EDAT- 2004/07/30 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/07/30 05:00
PHST- 2004/02/18 00:00 [received]
PHST- 2004/03/30 00:00 [revised]
PHST- 2004/03/30 00:00 [accepted]
PHST- 2004/07/30 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/07/30 05:00 [entrez]
AID - S0005272804001288 [pii]
AID - 10.1016/j.bbabio.2004.03.017 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2004 Jul 23;1658(1-2):23-30. doi: 
      10.1016/j.bbabio.2004.03.017.