PMID- 15284691
OWN - NLM
STAT- MEDLINE
DCOM- 20041221
LR  - 20220330
IS  - 1022-4742 (Print)
IS  - 1022-4742 (Linking)
VI  - 13
IP  - 2
DP  - 2004 Jul
TI  - Interleukin-6 (IL-6) and tumour necrosis factor-alpha in open and laparoscopic 
      cholecystectomy.
PG  - 153-6
AB  - Injury to the human body alters normal physiology across several systems and 
      these alterations are proportional to the extent of the injury. Physiological 
      response to minimally invasive surgery appears to be different than those of 
      traditional open surgery. Acute phase protein response appears to be one example. 
      The important cytokines that are known as major mediators of acute phase response 
      are interleukin-6 and TNF-alpha. Thirty patients were studied in which 14 
      underwent open cholecystectomy and 16 laparoscopic cholecystectomy. Three blood 
      samples were taken from each patient, one pre-operatively and 2 post operatively 
      at 4 and 24 hours. Interleukin-6 and Tumour Necrosis Factor-alpha (TNF-alpha) 
      were raised significantly in post operative blood sample in both groups but the 
      rise was much more in open group than laparoscopic group. This suggest less 
      stress response in laparoscopic group which also showed a direct effect on 
      patient convalescence in terms of less pain, less analgesic requirement and 
      shorter hospital stay
FAU - Haq, Z
AU  - Haq Z
AD  - Associate Professor of Surgery, Sylhet MAG Osmani Medical College.
FAU - Rahman, M
AU  - Rahman M
FAU - Siddique, M A
AU  - Siddique MA
FAU - Roy, R K
AU  - Roy RK
FAU - Rahman, A M
AU  - Rahman AM
FAU - Khatun, M
AU  - Khatun M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Bangladesh
TA  - Mymensingh Med J
JT  - Mymensingh medical journal : MMJ
JID - 9601799
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acute-Phase Reaction/blood/etiology
MH  - Adult
MH  - *Cholecystectomy, Laparoscopic/adverse effects
MH  - Female
MH  - Gallstones/blood/surgery
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Recovery of Function
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2004/07/31 05:00
MHDA- 2004/12/22 09:00
CRDT- 2004/07/31 05:00
PHST- 2004/07/31 05:00 [pubmed]
PHST- 2004/12/22 09:00 [medline]
PHST- 2004/07/31 05:00 [entrez]
PST - ppublish
SO  - Mymensingh Med J. 2004 Jul;13(2):153-6.