PMID- 15285709
OWN - NLM
STAT- MEDLINE
DCOM- 20050124
LR  - 20191108
IS  - 1476-0584 (Print)
IS  - 1476-0584 (Linking)
VI  - 3
IP  - 4 Suppl
DP  - 2004 Aug
TI  - ALVAC-HIV vaccines: clinical trial experience focusing on progress in vaccine 
      development.
PG  - S99-104
AB  - A decade of clinical trial experience with the preventive use of ALVAC-HIV 
      (Aventis Pasteur) has revealed important information on the safety and 
      immunogenicity of HIV vaccines in general. The ability to induce mucosal immune 
      responses and the feasibility of assessing those responses with a systemically 
      delivered HIV vaccine was recently shown with ALVAC-HIV. A critical advance for 
      the HIV vaccine field was the reported direct relationship between cellular 
      immune responses to ALVAC-HIV vaccine in human leukocyte antigen (HLA) B27 and 
      HLA B57 carriers, alleles linked with a favorable HIV prognosis in the setting of 
      natural infection. Other advances include the use of ALVAC-HIV as a heterologous 
      viral boost to enhance cellular responses to an adenovirus-HIV vaccine. All of 
      these observations have important implications for the future of HIV vaccines and 
      need to be considered in the design of the next generation of products.
FAU - Marovich, Mary A
AU  - Marovich MA
AD  - Division of Retrovirology, US Military HIV Research Program, Rockville, Maryland 
      20850, USA. mmarovich@hivresearch.org
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Rev Vaccines
JT  - Expert review of vaccines
JID - 101155475
RN  - 0 (AIDS Vaccines)
RN  - 0 (ALVAC vaccine)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - AIDS Vaccines/administration & dosage/adverse effects/*immunology
MH  - Clinical Trials, Phase III as Topic
MH  - Drug Administration Routes
MH  - HIV Infections/*immunology/*prevention & control
MH  - Humans
MH  - Viral Vaccines/administration & dosage/adverse effects/*immunology
RF  - 36
EDAT- 2004/08/03 05:00
MHDA- 2005/01/26 09:00
CRDT- 2004/08/03 05:00
PHST- 2004/08/03 05:00 [pubmed]
PHST- 2005/01/26 09:00 [medline]
PHST- 2004/08/03 05:00 [entrez]
AID - ERV0304S9 [pii]
AID - 10.1586/14760584.3.4.s99 [doi]
PST - ppublish
SO  - Expert Rev Vaccines. 2004 Aug;3(4 Suppl):S99-104. doi: 10.1586/14760584.3.4.s99.