PMID- 15286263
OWN - NLM
STAT- MEDLINE
DCOM- 20041227
LR  - 20220311
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 114
IP  - 2
DP  - 2004 Aug
TI  - Polymorphism of tumor necrosis factor-alpha and risk and severity of 
      bronchopulmonary dysplasia among very low birth weight infants.
PG  - e243-8
AB  - BACKGROUND: Preterm infants with bronchopulmonary dysplasia (BPD) exhibit 
      prolonged elevation of inflammatory indices in their tracheal aspirates. Tumor 
      necrosis factor-alpha (TNF-alpha) is a central mediator of the inflammatory 
      response. The adenine-containing alleles of TNF-alpha-308 and 
      lymphotoxin-alpha+250 have been associated with increased levels of TNF-alpha, 
      whereas the adenine allele of TNF-alpha-238 produces lower levels of TNF-alpha 
      after stimulation. High levels of TNF-alpha may promote chronic inflammation by 
      overwhelming counter-regulatory mechanisms and may lead to the development of 
      BPD. Low levels of TNF-alpha may decrease the risk and/or severity of BPD. 
      OBJECTIVE: To determine whether alleles of TNF-alpha play a role in the 
      susceptibility and/or severity of BPD among very low birth weight infants. 
      METHODS: Infants with birth weights of < or =1250 g were included. Genotypic 
      analyses (polymerase chain reaction-restriction fragment length polymorphism 
      assays) were performed with DNA extracted from whole-blood samples. RESULTS: 
      Infants who developed BPD (fraction of inspired oxygen at postconceptional age of 
      36 weeks of >0.21, n = 51) had a younger gestational age (mean +/- SD: 27 +/- 4 
      vs 29 +/- 2 weeks) and lower birth weight (853 +/- 184 vs 997 +/- 193 g) than did 
      infants without BPD (n = 69). The genotypic distributions of 
      lymphotoxin-alpha+250 and TNF-alpha-308 were comparable among the groups of 
      infants. However, the AA and GA TNF-alpha-238 genotypes were much less likely to 
      occur among infants with BPD than among infants without BPD. The adenine allele 
      of TNF-alpha-238 was absent among infants with severe BPD and occurred 
      significantly less often among infants with moderate or severe BPD, compared with 
      infants with mild BPD. The number of adenine alleles of TNF-alpha-238 was 
      correlated inversely with the severity of BPD (r = -.341). CONCLUSION: The 
      adenine allele of TNF-alpha-238 may reduce the risk and severity of BPD.
FAU - Kazzi, S Nadya J
AU  - Kazzi SN
AD  - Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Hutzel Women's 
      Hospital, 4707 St Antoine, Detroit, Michigan 48201, USA. nkazzi@med.wayne.edu
FAU - Kim, U Olivia
AU  - Kim UO
FAU - Quasney, Michael W
AU  - Quasney MW
FAU - Buhimschi, Irina
AU  - Buhimschi I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
CIN - Pediatrics. 2005 Jan;115(1):198-9; author reply 199. PMID: 15630015
MH  - Bronchopulmonary Dysplasia/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/mortality
MH  - Infant, Premature
MH  - *Infant, Very Low Birth Weight
MH  - Linkage Disequilibrium
MH  - Logistic Models
MH  - Male
MH  - Polymorphism, Genetic
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2004/08/03 05:00
MHDA- 2004/12/28 09:00
CRDT- 2004/08/03 05:00
PHST- 2004/08/03 05:00 [pubmed]
PHST- 2004/12/28 09:00 [medline]
PHST- 2004/08/03 05:00 [entrez]
AID - 114/2/e243 [pii]
AID - 10.1542/peds.114.2.e243 [doi]
PST - ppublish
SO  - Pediatrics. 2004 Aug;114(2):e243-8. doi: 10.1542/peds.114.2.e243.