PMID- 15286441
OWN - NLM
STAT- MEDLINE
DCOM- 20041014
LR  - 20131121
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 135
IP  - 1
DP  - 2004 Sep
TI  - Isodon japonicus decreases immediate-type allergic reaction and tumor necrosis 
      factor-alpha production.
PG  - 17-23
AB  - BACKGROUND: The immediate-type allergic reaction is involved in many allergic 
      diseases such as asthma, allergic rhinitis and sinusitis. The discovery of drugs 
      for the treatment of immediate-type allergic disease is a very important subject 
      in human health. Isodon japonicus Hara (Labiatae) (IJAE) has been used for 
      centuries as a traditional medicine in Korea and is known to have an 
      anti-inflammatory effect. However, its specific mechanism of action is still 
      unknown. In this report, we investigated the effect of IJAE on the immediate-type 
      allergic reaction and studied its possible mechanisms of action, focusing on the 
      mast cell-mediated allergic reaction. METHODS: IJAE extracts were anally 
      administered to mice for high and fast absorption. Compound 48/80-induced 
      mortality and compound 48/80- or immunoglobulin E (IgE)-induced histamine release 
      were measured to evaluate the antiallergic effects of IJAE. The effect of IJAE on 
      the model of local allergic reaction in vivo, passive cutaneous anaphylaxis 
      (PCA), was investigated. The production of tumor necrosis factor-alpha 
      (TNF-alpha) was measured by Western blotting. RESULTS: IJAE inhibited compound 
      48/80-induced systemic reactions and plasma histamine release in mice. IJAE 
      decreased the PCA reaction activated by anti-dinitrophenyl (DNP) IgE antibody. 
      IJAE dose-dependently reduced histamine release from rat peritoneal mast cells 
      activated by compound 48/80 or anti-DNP IgE. Furthermore, IJAE decreased the 
      production of TNF-alpha in phorbol 12-myristate 13-acetate plus calcium ionophore 
      A23187-stimulated human mast cells. CONCLUSION: Our findings provide evidence 
      that IJAE inhibits mast cell-derived immediate-type allergic reactions, and also 
      demonstrate the involvement of TNF-alpha in these effects. We propose the 
      clinical use of IJAE in mast cell-mediated immediate-type allergic diseases.
CI  - Copyright 2004 S. Karger AG, Basel
FAU - Shin, Tae-Yong
AU  - Shin TY
AD  - College of Pharmacy, Woosuk University, Jeonju, Jeonbuk 565-701, South Korea. 
      tyshin@woosuk.ac.kr
FAU - Kim, Sang-Hyun
AU  - Kim SH
FAU - Choi, Cheol-Hee
AU  - Choi CH
FAU - Shin, Hye-Young
AU  - Shin HY
FAU - Kim, Hyung-Min
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040729
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Dinitrobenzenes)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Administration, Rectal
MH  - Animals
MH  - Dinitrobenzenes/immunology
MH  - Dose-Response Relationship, Drug
MH  - Drugs, Chinese Herbal/administration & dosage/*pharmacology
MH  - Histamine/immunology
MH  - Hypersensitivity, Immediate/drug therapy/immunology/prevention & control/*therapy
MH  - Immunoglobulin E/immunology
MH  - *Isodon
MH  - Male
MH  - Mast Cells/*immunology
MH  - Mice
MH  - Models, Animal
MH  - *Phytotherapy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/*biosynthesis/immunology
MH  - p-Methoxy-N-methylphenethylamine/administration & dosage/immunology
EDAT- 2004/08/03 05:00
MHDA- 2004/10/16 09:00
CRDT- 2004/08/03 05:00
PHST- 2004/03/30 00:00 [received]
PHST- 2004/05/19 00:00 [accepted]
PHST- 2004/08/03 05:00 [pubmed]
PHST- 2004/10/16 09:00 [medline]
PHST- 2004/08/03 05:00 [entrez]
AID - 80038 [pii]
AID - 10.1159/000080038 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2004 Sep;135(1):17-23. doi: 10.1159/000080038. Epub 
      2004 Jul 29.