PMID- 15288699
OWN - NLM
STAT- MEDLINE
DCOM- 20041124
LR  - 20061115
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 39
IP  - 8
DP  - 2004 Aug
TI  - Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism and risk of 
      Alzheimer's disease in Italians.
PG  - 1249-52
AB  - Monocyte chemoattractant protein-1 (MCP-1) is a key molecule for monocyte 
      chemotaxis and tissue extravasation and for the modulation of leukocyte function 
      during inflammation. Upregulation of MCP-1 may occur in the brain of subjects 
      affected by Alzheimer's disease (AD) and MCP-1 levels in plasma and cerebrospinal 
      fluid have been proposed as biological markers for the inflammatory process that 
      accompanies AD pathogenesis. Importantly, serum levels and biological activity of 
      MCP-1 protein are strongly influenced by a single nucleotide polymorphism 
      occurring at position -2518 of the MCP-1 gene promoter. A recent study has 
      investigated the possible association between this gene polymorphism and AD in a 
      Spanish population, with negative results. Here, we performed a case-control 
      study to test whether the risk for AD might be influenced by the -2518 A/G 
      polymorphism of the MCP-1 gene in an ethnically homogeneous Italian population. 
      The GG genotype and the G allele of the MCP-1 gene polymorphism were 
      significantly more common in the AD group than in control individuals (P<0.0001) 
      A logistic regression analysis indicated that the GG genotype was an independent 
      risk factor for AD in our population. This effect was not influenced by the 
      presence of the APOE 4 high-risk allele, nor by the presence of other gene 
      variations associated with a pro-inflammatory phenotype. These findings indicate 
      that the -2518 A/G polymorphism of the MCP-1 gene is associated with AD in 
      Italians and confirm that inflammatory gene variations may be important 
      contributors in the development and progression of neurodegenerative disorders.
FAU - Pola, Roberto
AU  - Pola R
AD  - Laboratory of Vascular Biology and Genetics, Department of Medicine, A. Gemelli 
      University Hospital, Universita Cattolica del Sacro Cuore School of Medicine, 
      Rome, Italy. rob_pola@hotmail.com
FAU - Flex, Andrea
AU  - Flex A
FAU - Gaetani, Eleonora
AU  - Gaetani E
FAU - Proia, Anna S
AU  - Proia AS
FAU - Papaleo, Pierangelo
AU  - Papaleo P
FAU - Di Giorgio, Angela
AU  - Di Giorgio A
FAU - Straface, Giuseppe
AU  - Straface G
FAU - Pecorini, Giovanni
AU  - Pecorini G
FAU - Serricchio, Michele
AU  - Serricchio M
FAU - Pola, Paolo
AU  - Pola P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Apolipoproteins E)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*genetics/immunology
MH  - Apolipoproteins E/genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics/immunology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Homozygote
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/genetics
MH  - Interleukin-6/genetics
MH  - Italy
MH  - Logistic Models
MH  - Male
MH  - *Polymorphism, Genetic
EDAT- 2004/08/04 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/08/04 05:00
PHST- 2004/02/24 00:00 [received]
PHST- 2004/05/03 00:00 [revised]
PHST- 2004/05/04 00:00 [accepted]
PHST- 2004/08/04 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/08/04 05:00 [entrez]
AID - S0531556504001780 [pii]
AID - 10.1016/j.exger.2004.05.001 [doi]
PST - ppublish
SO  - Exp Gerontol. 2004 Aug;39(8):1249-52. doi: 10.1016/j.exger.2004.05.001.