PMID- 15289014
OWN - NLM
STAT- MEDLINE
DCOM- 20070913
LR  - 20071115
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 28
IP  - 10
DP  - 2004 Oct
TI  - High frequency of t(12;21)(p13;q22) in children with acute lymphoblastic leukemia 
      and known clinical outcome in southern Brazil.
PG  - 1033-8
AB  - The presence of the t(12;21)(p13;q22) distinguishes a subset of children with 
      acute lymphoblastic leukemia (ALL) that present a favorable prognosis. This is a 
      cryptic translocation difficult to detect through conventional cytogenetics. In 
      this study, bone marrow samples from 30 children with ALL from southern Brazil 
      were evaluated by fluorescence in situ hybridization (FISH) for the t(12;21), 
      using locus specific probes to detect the TEL/AML1 rearrangement. The selection 
      criteria included: age (0-12 years old); FAB classification (L1 or L2), absence 
      of specific clonal chromosomal aberrations; and adequate cellular integrity to 
      perform FISH analysis. A frequency of 40% of the t(12;21) was observed, in 
      addition to extra copies of the AML1 gene in 7.5% of patients. These findings 
      were analyzed in relation to the patient's clinical parameters and compared with 
      other pediatric populations.
FAU - Veiga, Loraine Beatriz Acosta
AU  - Veiga LB
AD  - Departamento de Genetica, Laboratorio de Citogenetica Humana, Universidade 
      Federal do Parana, Centro Politecnico, Jardim das Americas, Curitiba, PR 81531, 
      Brazil.
FAU - Coser, Virginia Maria
AU  - Coser VM
FAU - Cavalli, Luciane Regina
AU  - Cavalli LR
FAU - Cavalli, Iglenir Joao
AU  - Cavalli IJ
FAU - Rodrigues, Jacqueline Nunes
AU  - Rodrigues JN
FAU - Pereira, Waldir Veiga
AU  - Pereira WV
FAU - Pereira, Dalnei Veiga
AU  - Pereira DV
FAU - Lafayette, Thereza Christina Sampaio
AU  - Lafayette TC
FAU - Villalba, Benonio Terra
AU  - Villalba BT
FAU - Moreira, Mauber Eduardo Schultz
AU  - Moreira ME
FAU - Haddad, Bassem R
AU  - Haddad BR
FAU - de Souza Fonseca Ribeiro, Enilze Maria
AU  - de Souza Fonseca Ribeiro EM
LA  - eng
GR  - 1P30-CA-51008/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Bone Marrow/pathology
MH  - Brazil
MH  - Child
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Chromosomes, Human, Pair 21/*genetics
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Infant
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/drug therapy/*genetics
MH  - Prognosis
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
EDAT- 2004/08/04 05:00
MHDA- 2007/09/14 09:00
CRDT- 2004/08/04 05:00
PHST- 2003/11/04 00:00 [received]
PHST- 2004/02/09 00:00 [accepted]
PHST- 2004/08/04 05:00 [pubmed]
PHST- 2007/09/14 09:00 [medline]
PHST- 2004/08/04 05:00 [entrez]
AID - S0145212604000517 [pii]
AID - 10.1016/j.leukres.2004.02.004 [doi]
PST - ppublish
SO  - Leuk Res. 2004 Oct;28(10):1033-8. doi: 10.1016/j.leukres.2004.02.004.