PMID- 15289500
OWN - NLM
STAT- MEDLINE
DCOM- 20040824
LR  - 20201222
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 200
IP  - 3
DP  - 2004 Aug 2
TI  - A contribution of mouse dendritic cell-derived IL-2 for NK cell activation.
PG  - 287-95
AB  - Dendritic cells (DCs) play a predominant role in activation of natural killer 
      (NK) cells that exert their functions against pathogen-infected and tumor cells. 
      Here, we used a murine model to investigate the molecular mechanisms responsible 
      for this process. Two soluble molecules produced by bacterially activated myeloid 
      DCs are required for optimal priming of NK cells. Type I interferons (IFNs) 
      promote the cytotoxic functions of NK cells. IL-2 is necessary both in vitro and 
      in vivo for the efficient production of IFNgamma, which has an important 
      antimetastatic and antibacterial function. These findings provide new information 
      about the mechanisms that mediate DC-NK cell interactions and define a novel and 
      fundamental role for IL-2 in innate immunity.
FAU - Granucci, Francesca
AU  - Granucci F
AD  - Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza 
      della Scienza 2, 20126 Milano, Italy.
FAU - Zanoni, Ivan
AU  - Zanoni I
FAU - Pavelka, Norman
AU  - Pavelka N
FAU - Van Dommelen, Serani L H
AU  - Van Dommelen SL
FAU - Andoniou, Christopher E
AU  - Andoniou CE
FAU - Belardelli, Filippo
AU  - Belardelli F
FAU - Degli Esposti, Mariapia A
AU  - Degli Esposti MA
FAU - Ricciardi-Castagnoli, Paola
AU  - Ricciardi-Castagnoli P
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-2)
RN  - 187348-17-0 (Interleukin-12)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Cell Communication
MH  - Cytotoxicity, Immunologic
MH  - Dendritic Cells/*physiology
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-12/physiology
MH  - Interleukin-18/physiology
MH  - Interleukin-2/*physiology
MH  - Killer Cells, Natural/*immunology
MH  - *Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
PMC - PMC2211974
EDAT- 2004/08/04 05:00
MHDA- 2004/08/25 05:00
PMCR- 2005/02/02
CRDT- 2004/08/04 05:00
PHST- 2004/08/04 05:00 [pubmed]
PHST- 2004/08/25 05:00 [medline]
PHST- 2004/08/04 05:00 [entrez]
PHST- 2005/02/02 00:00 [pmc-release]
AID - jem.20040370 [pii]
AID - 20040370 [pii]
AID - 10.1084/jem.20040370 [doi]
PST - ppublish
SO  - J Exp Med. 2004 Aug 2;200(3):287-95. doi: 10.1084/jem.20040370.