PMID- 15291367
OWN - NLM
STAT- MEDLINE
DCOM- 20041230
LR  - 20220419
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 45
IP  - 5
DP  - 2004 May
TI  - Burkitt's lymphoma of the stomach: a case report with molecular cytogenetic 
      analysis.
PG  - 1055-9
AB  - In 1974, a 28-year-old man presented with a 12 cm sized ulcerated tumor involving 
      the middle third of the stomach, which was originally diagnosed as 
      "lymphosarcoma". Clinical recurrence of the lymphoma resulted in rapidly 
      progressing disease and the patient died 4 months after initial diagnosis. 
      Retrospective work-up of the 29-year-old tumor blocks revealed the typical 
      histologic appearance and phenotype (CD20, CD10, BCL-6 positive) of Burkitt's 
      lymphoma (BL) with a proliferation rate of 95%. By fluorescence in situ 
      hybridization (FISH). the tumor cells were shown to harbor an IGH-MYC fusion 
      indicating the presence of the hallmark Burkitt-translocation t(8;14)(q24;q32). 
      Considering the typical clinical features of BL requiring appropriate treatment 
      regimes the case presented here highlights the importance of modern 
      histopathologic and molecular cytogenetic techniques for the proper 
      classification of such rare lymphomas presenting at atypical sites.
FAU - Krugmann, Jens
AU  - Krugmann J
AD  - Institute of Pathology, University of Innsbruck, Austria. 
      jens.krugmann@uibk.ac.at
FAU - Tzankov, Alexandar
AU  - Tzankov A
FAU - Fiegl, Michael
AU  - Fiegl M
FAU - Dirnhofer, Stephan
AU  - Dirnhofer S
FAU - Siebert, Reiner
AU  - Siebert R
FAU - Erdel, Martin
AU  - Erdel M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Adult
MH  - Burkitt Lymphoma/*diagnosis
MH  - Cytogenetic Analysis
MH  - Fatal Outcome
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - Immunophenotyping
MH  - Male
MH  - Oncogene Proteins, Fusion/analysis
MH  - Proto-Oncogene Proteins c-myc/genetics
MH  - Stomach Neoplasms/*diagnosis
EDAT- 2004/08/05 05:00
MHDA- 2004/12/31 09:00
CRDT- 2004/08/05 05:00
PHST- 2004/08/05 05:00 [pubmed]
PHST- 2004/12/31 09:00 [medline]
PHST- 2004/08/05 05:00 [entrez]
AID - 10.1080/10428190310001623847 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2004 May;45(5):1055-9. doi: 10.1080/10428190310001623847.