PMID- 15291902
OWN - NLM
STAT- MEDLINE
DCOM- 20050210
LR  - 20061115
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 59
IP  - 9
DP  - 2004 Sep
TI  - Exposure to house dust endotoxin and allergic sensitization in adults.
PG  - 946-52
AB  - BACKGROUND: It has been suggested that exposure to elevated levels of endotoxin 
      decreases the risk of allergic sensitization. OBJECTIVE: To examine the 
      associations between current exposure to bacterial endotoxin in house dust and 
      allergic sensitization in adults. METHODS: In 1995-1996, we conducted a nested 
      case-control study following a cross-sectional study performed within the 
      European Community Respiratory Health Survey (ECRHS). Data of 350 adults aged 
      25-50 years was analysed. Allergic sensitization was assessed by measurement of 
      specific immunoglobulin E (IgE) against several inhalant allergens. Living room 
      floor dust samples were taken. The endotoxin content was quantified using a 
      chromogenic kinetic Limulus amoebocyte lysate test. RESULTS: Multiple logistic 
      regression analysis showed a negative association between exposure to house dust 
      endotoxin and severe allergic sensitization. Odds ratios (95% CI) adjusted for 
      place of residence, gender, age, and 'caseness' were 0.80 (0.64-1.00) for 
      sensitization to >/=1 allergen and 0.72 (0.56, 0.92) for sensitization to >/=2 
      allergens using 3.5 kU/l as a cut-off value for sensitization. With regard to 
      single allergens, the protective effect of endotoxin was strongest for pollen 
      sensitization [aOR (95% CI) = 0.74 (0.58, 0.93)]. CONCLUSION: Our results 
      indicate that current exposure to higher levels of house dust endotoxin might be 
      associated with a decreased odds of allergic sensitization in adults.
FAU - Gehring, U
AU  - Gehring U
AD  - GSF - National Research Center for Environment and Health, Institute of 
      Epidemiology, Neuherberg, Germany.
FAU - Bischof, W
AU  - Bischof W
FAU - Schlenvoigt, G
AU  - Schlenvoigt G
FAU - Richter, K
AU  - Richter K
FAU - Fahlbusch, B
AU  - Fahlbusch B
FAU - Wichmann, H-E
AU  - Wichmann HE
FAU - Heinrich, J
AU  - Heinrich J
CN  - INGA study group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 0 (Dust)
RN  - 0 (Endotoxins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/immunology
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Dust/*immunology
MH  - Endotoxins/*pharmacology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*prevention & control
MH  - Immunoglobulin E/blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
EDAT- 2004/08/05 05:00
MHDA- 2005/02/11 09:00
CRDT- 2004/08/05 05:00
PHST- 2004/08/05 05:00 [pubmed]
PHST- 2005/02/11 09:00 [medline]
PHST- 2004/08/05 05:00 [entrez]
AID - ALL551 [pii]
AID - 10.1111/j.1398-9995.2004.00551.x [doi]
PST - ppublish
SO  - Allergy. 2004 Sep;59(9):946-52. doi: 10.1111/j.1398-9995.2004.00551.x.