PMID- 15291904
OWN - NLM
STAT- MEDLINE
DCOM- 20050210
LR  - 20040804
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 59
IP  - 9
DP  - 2004 Sep
TI  - Determinants of neonatal IgE level: parity, maternal age, birth season and 
      perinatal essential fatty acid status in infants of atopic mothers.
PG  - 961-8
AB  - OBJECTIVE: The hygiene hypothesis suggests that the protective 'siblings effect' 
      against atopic diseases such as atopic dermatitis, allergic asthma and hay fever 
      is a result of recurrent infections during early childhood. A recent study and 
      review have indicated that this protective effect may already arise in utero. 
      Lower n-3 essential fatty acid (EFA) status is associated with increased parity, 
      and EFA status has also been related to atopy. The present study confirms the 
      negative association between parity and neonatal immunoglobulin E (IgE) levels 
      and further unravel the role of perinatal EFA status. METHODOLOGY: In a 
      prospective cohort study in 184 atopic mothers and their neonates, we 
      simultaneously measured serum total IgE and EFA levels in plasma phospholipids, 
      both in the mother at 34-36 weeks of gestation and in the neonate at the age of 1 
      week. Linear regression analysis was used to estimate the effect of parity on 
      maternal and neonatal IgE and EFA status, and the independent effects of parity 
      and EFA status on IgE, controlling for confounding factors such as maternal age 
      and birth season. RESULTS: Parity was associated with lower neonatal IgE level (P 
      < 0.01), as well as with lower docosahexanoic acid (DHA, 22:6n-3) status of the 
      mother (P = 0.01) but not of the neonate (P > 0.69). In the multivariate 
      analysis, higher parity, higher maternal IgE, lower maternal age and birth in the 
      first 3 months of the year were independently associated with neonatal IgE level. 
      No association was detected between maternal or neonatal EFA status and neonatal 
      IgE. CONCLUSIONS: As neonatal total serum IgE is predictive of later atopy, our 
      results support the hypothesis that the sibling effect in atopy is already being 
      programmed in utero. Our data also confirm earlier findings that DHA status is 
      lower in multiparous women, but this did not confound the relation between parity 
      and neonatal IgE.
FAU - van Gool, C J A W
AU  - van Gool CJ
AD  - Department of Epidemiology, Nutrition and Toxicology Research Institute 
      Maastricht, Maastricht University, Maastricht, The Netherlands.
FAU - Thijs, C
AU  - Thijs C
FAU - Dagnelie, P C
AU  - Dagnelie PC
FAU - Henquet, C J M
AU  - Henquet CJ
FAU - van Houwelingen, A C
AU  - van Houwelingen AC
FAU - Schrander, J
AU  - Schrander J
FAU - Menheere, P P C A
AU  - Menheere PP
FAU - van den Brandt, P A
AU  - van den Brandt PA
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Fatty Acids, Essential)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Fatty Acids, Essential/*blood
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*etiology
MH  - Immunoglobulin E/*blood
MH  - Infant, Newborn
MH  - Male
MH  - *Maternal Age
MH  - *Parity
MH  - Seasons
EDAT- 2004/08/05 05:00
MHDA- 2005/02/11 09:00
CRDT- 2004/08/05 05:00
PHST- 2004/08/05 05:00 [pubmed]
PHST- 2005/02/11 09:00 [medline]
PHST- 2004/08/05 05:00 [entrez]
AID - ALL528 [pii]
AID - 10.1111/j.1398-9995.2004.00528.x [doi]
PST - ppublish
SO  - Allergy. 2004 Sep;59(9):961-8. doi: 10.1111/j.1398-9995.2004.00528.x.