PMID- 15291959
OWN - NLM
STAT- MEDLINE
DCOM- 20050214
LR  - 20240411
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 2
DP  - 2004 Aug 3
TI  - The ECOS-16 questionnaire for the evaluation of health related quality of life in 
      post-menopausal women with osteoporosis.
PG  - 41
AB  - BACKGROUND: The aim of this study is to validate the questionnaire ECOS-16 
      (Assessment of health related quality of life in osteoporosis) for the evaluation 
      of health related quality of life (HRQoL) in post-menopausal women with 
      osteoporosis. METHODS: An observational, prospective and multi-centre study was 
      carried out among post-menopausal women with osteoporosis in primary care centres 
      and hospital outpatient clinics. All patients attended 2 visits: at baseline and 
      at 6 months. In addition, the subgroup of outpatients attended another visit a 
      month after the baseline to assess the test-retest reliability. The psychometric 
      properties of the questionnaire were evaluated in terms of feasibility, validity 
      (content validity and construct validity) and internal consistency in baseline, 
      and in terms of test-retest reliability and responsiveness to change in visit at 
      month and visit at 6 months, respectively. In all visits, ECOS-16, EUROQoL-5D 
      (EQ-5D) and four 7-point items about health status (general health status, back 
      pain, limitation in daily activities and emotional status) were administered, 
      whereas only outpatients were given MINI-OQLQ (Mini Osteoporosis Quality of Life 
      Questionnaire), besides all clinical variables; and sociodemographic variables at 
      baseline. RESULTS: 316 women were consecutively included, 212 from primary care 
      centres and 104 from hospital outpatient clinics. Feasibility: 94.3% of patients 
      answered all items of the questionnaire. The mean administration time was 12.3 
      minutes. VALIDITY: factor analysis suggested that the questionnaire was 
      unidimensional. In the multivariate analysis, patients with vertebral fractures, 
      co-morbidity and a lower education level showed to have worse HRQoL. Moderate to 
      high correlations were found between the ECOS-16 score and the other health 
      status questionnaires (0.47-0.82). Reliability: internal consistency (Cronbach's 
      alpha) was 0.92 and test-retest reliability (ICC) was 0.80. Responsiveness to 
      change: ECOS-16 scores increased according to change perceived by the patient, as 
      well as the effect size (ranges between 1.35 to 0.43), the greater the perception 
      of change in patients' general health status, the greater the changes in 
      patients' scores. The Minimal Clinically Important Difference (MCID) suggested a 
      change of 0.5 points in the ECOS-16 score, representing the least improvement in 
      general health status due to their osteoporosis: "slightly better". CONCLUSION: 
      ECOS-16 has been proven preliminarily to have good psychometric properties, so 
      that it can be potentially a useful tool to evaluate HRQoL of post-menopausal 
      women with osteoporosis in research and routine clinical practice.
FAU - Badia, Xavier
AU  - Badia X
AD  - Health Outcomes Research (HOR) Europe, Barcelona, Spain. xbadia@hor-europe.com
FAU - Diez-Perez, Adolfo
AU  - Diez-Perez A
FAU - Lahoz, Raquel
AU  - Lahoz R
FAU - Lizan, Luis
AU  - Lizan L
FAU - Nogues, Xavier
AU  - Nogues X
FAU - Iborra, Jordi
AU  - Iborra J
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20040803
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - Aged
MH  - Female
MH  - Fractures, Bone/etiology
MH  - Humans
MH  - Low Back Pain/etiology
MH  - Middle Aged
MH  - Observation
MH  - Osteoporosis/*physiopathology/psychology
MH  - Outpatient Clinics, Hospital
MH  - Pain Measurement
MH  - Postmenopause/physiology/*psychology
MH  - Primary Health Care
MH  - Prospective Studies
MH  - Psychometrics/*instrumentation
MH  - Quality of Life/*psychology
MH  - *Sickness Impact Profile
MH  - Social Class
MH  - Spain
MH  - *Surveys and Questionnaires/*statistics & numerical data
PMC - PMC514569
EDAT- 2004/08/05 05:00
MHDA- 2005/02/16 09:00
PMCR- 2004/08/03
CRDT- 2004/08/05 05:00
PHST- 2003/12/09 00:00 [received]
PHST- 2004/08/03 00:00 [accepted]
PHST- 2004/08/05 05:00 [pubmed]
PHST- 2005/02/16 09:00 [medline]
PHST- 2004/08/05 05:00 [entrez]
PHST- 2004/08/03 00:00 [pmc-release]
AID - 1477-7525-2-41 [pii]
AID - 10.1186/1477-7525-2-41 [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2004 Aug 3;2:41. doi: 10.1186/1477-7525-2-41.