PMID- 15292847
OWN - NLM
STAT- MEDLINE
DCOM- 20050104
LR  - 20191026
IS  - 0761-8425 (Print)
IS  - 0761-8425 (Linking)
VI  - 21
IP  - 3 Pt 1
DP  - 2004 Jun
TI  - [Involvement of dendritic cells in allergic airway diseases].
PG  - 549-55
AB  - INTRODUCTION: Dendritic cells (DCs) are able to present antigen to T lymphocytes 
      and to orientate the immune response towards a Th1 or a Th2 type. STATE OF THE 
      ART: The aim of this report is to present different studies comparing DCs from 
      allergic patients with those from healthy subjects using in vivo and in vitro 
      experimental conditions. These studies have demonstrated that cellules 
      dentritiquess from house dust mite allergic patients:i) take up house dust mite 
      allergen more efficiently, ii) after stimulation by house dust mite allergen, 
      secrete a restricted panel of cytokines and chemokines, and express 
      characteristic co-stimulatory molecules, favoring a Th2 profile, iii) after 
      stimulation by house dust mite allergen, induce Th2 cytokines secretion by T 
      lymphocytes, and iv) favor an allergen-specific Th2 airway inflammatory response 
      in an in vivo model of humanized mice. PERSPECTIVES: Functional modulation of DC 
      could be a new therapeutic concept in allergic airway diseases. CONCLUSIONS: 
      These results show phenotypic and functional specificities of DC from house dust 
      mite allergic patients, and suggest a key-role for cellules dentritiques in the 
      pathogenesis of allergen-dependent airway inflammatory response.
FAU - Deslee, G
AU  - Deslee G
AD  - INSERM U416, IFR 17, Institut Pasteur, Lille, France.
FAU - Hammad, H
AU  - Hammad H
FAU - Rataczak, C
AU  - Rataczak C
FAU - Just, N
AU  - Just N
FAU - Tillie-Leblond, I
AU  - Tillie-Leblond I
FAU - Lebargy, F
AU  - Lebargy F
FAU - Pestel, J
AU  - Pestel J
FAU - Tonnel, A-B
AU  - Tonnel AB
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Implication des cellules dendritiques en pathologie respiratoire allergique.
PL  - France
TA  - Rev Mal Respir
JT  - Revue des maladies respiratoires
JID - 8408032
SB  - IM
MH  - Dendritic Cells/*physiology
MH  - Humans
MH  - Respiratory Hypersensitivity/*immunology
RF  - 35
EDAT- 2004/08/05 05:00
MHDA- 2005/01/05 09:00
CRDT- 2004/08/05 05:00
PHST- 2004/08/05 05:00 [pubmed]
PHST- 2005/01/05 09:00 [medline]
PHST- 2004/08/05 05:00 [entrez]
AID - MDOI-RMR-06-2004-21-3-0761-8425-101019-ART16 [pii]
AID - 10.1016/s0761-8425(04)71359-5 [doi]
PST - ppublish
SO  - Rev Mal Respir. 2004 Jun;21(3 Pt 1):549-55. doi: 10.1016/s0761-8425(04)71359-5.