PMID- 15295706
OWN - NLM
STAT- MEDLINE
DCOM- 20040917
LR  - 20061115
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 190
IP  - 5
DP  - 2004 Sep 1
TI  - Quantitative analysis of Epstein-Barr virus (EBV)-specific CD8+ T cells in 
      patients with chronic active EBV infection.
PG  - 985-8
AB  - To clarify the pathogenesis of chronic active Epstein-Barr virus (EBV) infection, 
      EBV-specific CD8+ T cells were enumerated, by use of human leukocyte antigen 
      (HLA)-A*2402-restricted tetramers, in 8 patients with chronic active EBV 
      infection, 10 patients with infectious mononucleosis, and 16 EBV-seropositive 
      healthy control subjects. In most of the patients with chronic active EBV 
      infection, EBV-specific CD8+ T cells were not detected. Of note, latent membrane 
      protein 2-specific CD8+ T cells were not detectable in any patients with chronic 
      active EBV infection. In contrast, EBV-specific CD8+ T cells were detected in 
      patients with infectious mononucleosis and in healthy control subjects. Low 
      frequencies of EBV-specific CD8+ T cells may be one of the immunological features 
      of chronic active EBV infection.
FAU - Sugaya, Naomi
AU  - Sugaya N
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, 
      Tsurumai-cho, Showa-ku, Japan.
FAU - Kimura, Hiroshi
AU  - Kimura H
FAU - Hara, Shinya
AU  - Hara S
FAU - Hoshino, Yo
AU  - Hoshino Y
FAU - Kojima, Seiji
AU  - Kojima S
FAU - Morishima, Tsuneo
AU  - Morishima T
FAU - Tsurumi, Tatsuya
AU  - Tsurumi T
FAU - Kuzushima, Kiyotaka
AU  - Kuzushima K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040723
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA-A Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amino Acid Sequence
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Child
MH  - Chronic Disease
MH  - Epstein-Barr Virus Infections/*immunology/virology
MH  - HLA-A Antigens/chemistry/immunology
MH  - Herpesvirus 4, Human/*immunology
MH  - Humans
MH  - Infectious Mononucleosis/*immunology/virology
MH  - Lymphocyte Activation
EDAT- 2004/08/06 05:00
MHDA- 2004/09/21 05:00
CRDT- 2004/08/06 05:00
PHST- 2004/01/14 00:00 [received]
PHST- 2004/03/29 00:00 [accepted]
PHST- 2004/08/06 05:00 [pubmed]
PHST- 2004/09/21 05:00 [medline]
PHST- 2004/08/06 05:00 [entrez]
AID - JID32379 [pii]
AID - 10.1086/423285 [doi]
PST - ppublish
SO  - J Infect Dis. 2004 Sep 1;190(5):985-8. doi: 10.1086/423285. Epub 2004 Jul 23.