PMID- 15300499
OWN - NLM
STAT- MEDLINE
DCOM- 20041015
LR  - 20061115
IS  - 0172-4614 (Print)
IS  - 0172-4614 (Linking)
VI  - 25
IP  - 4
DP  - 2004 Aug
TI  - [Cerebral perfusion sonography in comparison with perfusion MRT: a study with 
      healthy volunteers].
PG  - 263-9
AB  - AIM: Perfusion harmonic imaging (PHI) has been used for several years now in 
      neurological as well as other patients. The aim of the study was to compare PHI 
      with perfusion-weighted MR tomography (pMRT) for the evaluation of cerebral 
      parenchymal perfusion. Furthermore, the influence of different trigger intervals 
      on the contrast kinetics in PHI was analysed. METHOD: Fifteen healthy individuals 
      were evaluated with two transtemporal PHI investigations and one pMRT. In PHI, 62 
      time-triggered images at two different trigger intervals (1 and 0.4 Hz) were 
      recorded after an intravenous bolus of 2 ml of SonoVue(R). pMRT was carried out 
      according to a standard technique using 0.2 mmol/kg Gadolinium-DTPA (Magnevist) 
      and T2*-weighted EPI-sequences. Time-intensity curves of PHI and pMRT-determined 
      data including peak intensity (PI), time-to-peak-intensity (TTP [s]), and 
      area-under-the-curve (AUC) were calculated off-line from 4 regions of interest: 
      ipsi- and contralateral thalamus (i-TH, k-TH), lentiform nucleus (NUC), and white 
      matter (ML). These parameters were compared between the data sets of the two 
      different trigger intervals. Additionally, ratios of the above parameters were 
      calculated to compare the two methods (TH/NUC and TH/ML). RESULTS: Comparison of 
      the two trigger intervals showed significantly lower AUC-values at the higher 
      trigger interval, while the trigger interval had no significant impact on PI- and 
      TTP- values. A good correlation was seen between the trigger intervals for 
      AUC-values and, to a lesser extent, for PI-values. TTP-values did not correlate. 
      TTP was the only depth-independent parameter. There was no significant difference 
      between PHI and pMRT in 10 of 12 parameter ratios analysed. Merely the PI-ratio 
      of i-TH/ML was significantly different at both trigger intervals. CONCLUSION: 
      Regarding the development of adequate set-ups for transcranial PHI, further 
      parameters with impact on contrast agent kinetics (MI, dose of contrast agent) 
      have to be taken into account in addition to the trigger interval. Our findings 
      suggest that, within certain limits, PHI is an imaging technique representing a 
      valuable alternative to MR perfusion imaging, with the TTP representing the most 
      reliable parameter. The AUC is useful for semi-quantitative evaluation of brain 
      perfusion.
FAU - Harrer, J U
AU  - Harrer JU
AD  - Klinik fur Neurologie des Universitatsklinikums Aachen. 
      Judith.Harrer@post.rwth-aachen.de
FAU - Klotzsch, C
AU  - Klotzsch C
FAU - Stracke, C P
AU  - Stracke CP
FAU - Moller-Hartmann, W
AU  - Moller-Hartmann W
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Zerebrale Perfusionssonographie im Vergleich zur Perfusions-MRT: Eine 
      Normalprobandenstudie.
PL  - Germany
TA  - Ultraschall Med
JT  - Ultraschall in der Medizin (Stuttgart, Germany : 1980)
JID - 8303585
SB  - IM
MH  - Brain/*anatomy & histology
MH  - Echoencephalography/*methods
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Reference Values
EDAT- 2004/08/10 05:00
MHDA- 2004/10/16 09:00
CRDT- 2004/08/10 05:00
PHST- 2004/08/10 05:00 [pubmed]
PHST- 2004/10/16 09:00 [medline]
PHST- 2004/08/10 05:00 [entrez]
AID - 10.1055/s-2004-813192 [doi]
PST - ppublish
SO  - Ultraschall Med. 2004 Aug;25(4):263-9. doi: 10.1055/s-2004-813192.